免疫缺陷模型
免疫缺陷模型是指由于先天遗传突变或者用人工方法造成的免疫系统上一种或者多种免疫成分存在缺陷或者缺失的小鼠，赛业生物自研C‑NKG重度免疫缺陷小鼠，缺失成熟T/B/NK细胞，利于各类人源细胞、肿瘤移植，适配多类科研，已有四十余篇客户引用文献。
免疫缺陷模型
免疫缺陷模型是指由于先天遗传突变或者用人工方法造成的免疫系统上一种或者多种免疫成分（B细胞、T细胞、NK细胞等）存在缺陷或者缺失的小鼠，随着基因编辑技术的不断发展，越来越多的免疫缺陷小鼠品系被研发出来，被广泛应用于肿瘤学（比如肿瘤生长、转移、抗肿瘤药物筛选）、免疫学（比如免疫细胞发育增殖机制、免疫疾病发生机理）、传染病学（比如病毒/细菌性传染病致病机制）、干细胞生物学（比如人源干细胞移植）等研究领域。其中，重度免疫缺陷小鼠由于T、B和NK免疫细胞的缺乏，可高效地植入人造血干细胞（HSC）、人外周血单个核细胞（PBMC）、人源肿瘤细胞系来源的异种移植物（CDX）、患者肿瘤组织来源的异种移植物（PDX）或其他成体干细胞及组织，广泛应用于人源化小鼠的构建。
明星产品C‑NKG小鼠是赛业生物通过在NOD‑Scid品系上敲除Il2rg基因而自主研发的一款重度免疫缺陷小鼠，C‑NKG小鼠缺乏成熟的T、B和NK免疫细胞，补体活性降低，巨噬细胞对人源细胞吞噬作用减弱，可用于人造血干细胞（HSC）、外周血单个核细胞（PBMC），患者来源的异种移植物（PDX）或成体干细胞和组织的高效移植，是目前公认的免疫缺陷程度最高的模型之一，是可广泛用于肿瘤、免疫、自身免疫性疾病、免疫治疗疫苗、移植物抗宿主病（GvHD）和药物安全性评估等领域研究的优秀模型，目前C‑NKG系列产品客户发表引用文献已超过40篇。
免疫缺陷模型列表
| 产品编号 | 产品名称 | 品系背景 | 应用领域 | 订购 |
|---|
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免疫缺陷模型验证数据
1. C‑NKG小鼠B、T和NK细胞检测
2. AG129小鼠免疫细胞检测
免疫缺陷模型精选文献
Proteasome‑guided haem signalling axis contributes to T cell exhaustion
Nature（2026）丨C‑NKG
RPSA‑OLFM4 axis governs neutrophil migration against bacterial infection and sepsis
Nature Communications（2026）丨C‑NKG
KLRG1 silencing increases the efficacy of CAR NK cell therapy against colon cancer via SHP‑2/ZAP‑70/NF‑κB signal pathway
Journal of Translational Medicine（2026）丨C‑NKG
PER2 knockdown drives immunotherapy resistance in gastric cancer via metabolic reprogramming of myeloid‑derived suppressor cells
Cancer & Metabolism（2026）丨huPBMC‑C‑NKG
Hantaan virus infection induces human mucosal‑associated invariant T cell pyroptosis through IRE1α pathway
Communications Biology（2025）丨huPBMC‑C‑NKG
Amplifying antigen‑induced cellular responses with proximity labelling
Nature（2025）丨huPBMC‑C‑NKG
An epitope‑directed mRNA vaccine inhibits tumor metastasis through the blockade of MICA/B α1/2 shedding
Cell Reports Medicine（2025）丨huPBMC‑C‑NKG
Identification and validation of intratumoral microbiome associated with sensitization to immune checkpoint inhibitors
Cell Reports Medicine（2025）丨huPBMC‑C‑NKG
Multidimensional mapping of stimulation‑responsive regulatory elements and candidate causal variants in T cell activation
Science Advances（2025）丨C‑NKG
A Gremlin 1‑expressing splenic niche cell population restrains chronic myeloid leukemia by antagonizing the BMP pathway
Nature Cancer（2025）丨C‑NKG
DHX34 deficiency triggers tumor‑intrinsic immunity via a dsRNA‑mediated type I interferon pathway activation in HCC
Neoplasia（2025）丨C‑NKG
Tumor microenvironment‑associated oxidative stress impairs SIRT1 secretion to suppress anti‑tumor immune response
Cell Reports（2025）丨C‑NKG
Inhibition of PINK1 senses ROS signaling to facilitate neuroblastoma cell pyroptosis
Autophagy（2025）丨C‑NKG
Interleukin‑33 (IL‑33) promotes DNA damage‑resistance in lung cancer
Cell Death & Disease（2025）丨C‑NKG
Preclinical evaluation of CAR‑T cell immunotherapy with a fully human EpCAM‑specific scFv against pancreatic cancer
Cancer Immunology, Immunotherapy（2025）丨C‑NKG
Human Immune System Reconstitution in NOD/Shi‑Prkdcscid Il2rgem1/Cyagen Mice to Study HIV Infection: Challenges and Pitfalls
Life（2025）丨C‑NKG
Single‑cell data‑driven design of armed oncolytic virus to boost cooperative innate‑adaptive immunity against cancer
Molecular Therapy（2025）丨C‑NKG
A novel HVEM‑Fc recombinant protein for lung cancer immunotherapy
Journal of Experimental & Clinical Cancer Research: CR（2025）丨C‑NKG
Micropeptide hSPAR regulates glutamine levels and suppresses mammary tumor growth via a TRIM21‑P27KIP1‑mTOR axis
The EMBO Journal（2025）丨C‑NKG
SERINC2‑mediated serine metabolism promotes cervical cancer progression and drives T cell exhaustion
International Journal of Biological Sciences（2025）丨C‑NKG
A self‑activated and protective module enhances the preclinical performance of allogeneic anti‑CD70 CAR‑T cells
Frontiers in Immunology（2025）丨C‑NKG
FOS‑driven inflammatory CAFs promote colorectal cancer liver metastasis via the SFRP1‑FGFR2‑HIF1 axis
Theranostics（2025）丨C‑NKG
A Novel 167‑Amino Acid Protein Encoded by CircPCSK6 Inhibits Intrahepatic Cholangiocarcinoma Progression via IKBα Ubiquitination
Advanced Science（2025）丨C‑NKG
YTHDC1 negatively regulates UBE3A to influence RAD51 ubiquitination and inhibit apoptosis in colorectal cancer cells
Scientific Reports（2025）丨C‑NKG
Temporal responsive vesicle‑INFγ aptamer‑PEI/HA system targeted activation of B‑CD4T‑Tfh‑CD8T cells cascade inhibits TNBC progression
Nano Today（2025）丨huHSC‑C‑NKG
LncRNA TCL6 regulates miR‑876–5p/MYL2 axis to suppress breast cancer progression
Translational Oncology（2025）丨huHSC‑C‑NKG
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