智鼠故事 
KS (inducible) 小鼠
复苏/繁育服务
自发肿瘤模型
* 使用本品系发表的文献需注明：KS (inducible) 小鼠 mice (Catalog C001514) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
只
基本信息
产品名称
KS (inducible) 小鼠
产品编号
C001514
基因名
品系背景
C57BL/6JCya
基因别称
ras；p21B；K-Ras；K-ras；Kras2；Ki-ras；Kras-2；K-Ras 2；c-K-ras；c-Ki-ras
模型分类
自发肿瘤模型
染色体
6
更多信息
* 使用本品系发表的文献需注明：KS (inducible) 小鼠 mice (Catalog C001514) were purchased from Cyagen.
品系描述
KS (inducible)小鼠是通过将LSL-K-ras G12D小鼠（条件性过表达K-Ras G12D突变基因小鼠品系，产品编号：C001064）和Sftpc-MerCreMer小鼠（Ⅱ型肺泡细胞特异性Cre重组酶表达小鼠，产品编号：C001501）进行交配，并通过他莫昔芬诱导来构建的诱导型（inducible）肺癌模型。他莫昔芬可以在子代小鼠的Ⅱ型肺泡细胞中触发Cre重组酶介导的loxP位点之间的序列重组，导致Ⅱ型肺泡细胞中的Loxp-Stop-Loxp（LSL）基因沉默元件被特异性地删除，从而使K-Ras G12D突变基因能够在肺部组织中选择性地表达。
相关疾病：
Schimmelpenning-Feuerstein-Mims Syndrome
Oculoectodermal Syndrome
Cardiofaciocutaneous Syndrome 2
Noonan Syndrome 3
Arteriovenous Malformations of the Brain
Ras-Associated Autoimmune Leukoproliferative Disorder
Pancreatic Cancer
Gastric Cancer
Lung Cancer
Juvenile Myelomonocytic Leukemia
Bladder Cancer
Noonan Syndrome 1
Cardiofaciocutaneous Syndrome 1
Lung Sarcomatoid Carcinoma
Leukemia, Acute Myeloid
Lung Cancer Susceptibility 3
Encephalocraniocutaneous Lipomatosis
Lung Squamous Cell Carcinoma
Plasma Cell Neoplasm
Pilocytic Astrocytoma
Thyroid Cancer
Rasopathy
Diffuse Gastric and Lobular Breast Cancer Syndrome
Pseudo-Turner Syndrome
Breast Adenocarcinoma
Chronic Myelogenous Leukemia, Bcr-Abl1 Positive
Myeloma, Multiple
Gallbladder Cancer
Leukemia, Chronic Myeloid
Adenoid Cystic Carcinoma
Capillary Malformation-Arteriovenous Malformation 1
Nevus, Epidermal
Pilomyxoid Astrocytoma
Noonan Syndrome and Noonan-Related Syndrome
Differentiated Thyroid Carcinoma
Ovarian Cancer
Pancreatic Adenocarcinoma
Angiosarcoma
Thyroid Gland Medullary Carcinoma
Thyroid Carcinoma, Familial Medullary
Lynch Syndrome
Bladder Urothelial Carcinoma
Gastrointestinal Stromal Tumor
Skin Melanoma
Gastric Adenocarcinoma
Esophageal Cancer
Hereditary Breast Ovarian Cancer Syndrome
Leukemia, Chronic Lymphocytic
Hepatocellular Carcinoma
应用领域
非小细胞肺癌（Non small cell lung cancer, NSCLC）
