智鼠故事 
HBB-bs&HBB-bt DKO 小鼠
复苏/繁育服务
其他模型
* 使用本品系发表的文献需注明：HBB-bs&HBB-bt DKO 小鼠 mice (Catalog C001508) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
只
品系描述
Hbb-bs&Hbb-bt DKO小鼠是利用基因编辑技术同时敲除C57BL/6JCya小鼠Hbb-bs基因和Hbb-bt基因所构建的β地中海贫血疾病模型。该模型纯合致死，杂合小鼠呈现血红蛋白含量、红细胞计数、红细胞压积、平均红细胞血红蛋白浓度、红细胞分布宽度、血小板数、脾脏大小和红细胞形态等指标异常的严重地中海贫血典型特征并具有生育能力。因此，杂合Hbb-bs&Hbb-btDKO小鼠可用于与β地中海贫血相关的研究。
相关疾病：
Hemoglobin Lepore-Beta-Thalassemia Syndrome
Fetal Hemoglobin Quantitative Trait Locus 1
Thalassemia
Sickle Cell Disease
Beta-Thalassemia, Dominant Inclusion Body Type
Fetal Hemoglobin Quantitative Trait Locus 1
Beta-Thalassemia
Heinz Body Anemias
Erythrocytosis, Familial, 6
Methemoglobinemia, Beta Type
Beta-Thalassemia Intermedia
Beta-Thalassemia Major
Hemoglobin C Disease
Hemoglobin E Disease
Hemoglobin E-Beta-Thalassemia Syndrome
Sickle Cell-Hemoglobin C Disease Syndrome
Hemoglobin D Disease
Malaria
Hemoglobinopathy
Deficiency Anemia
Hemoglobin Se Disease
Sickle Cell Disease and Related Diseases
Congenital Methemoglobinemia
Hemoglobin C-Beta-Thalassemia Syndrome
Sickle Cell-Beta-Thalassemia Disease Syndrome
Hemoglobin Lepore-Beta-Thalassemia Syndrome
Hereditary Persistence of Fetal Hemoglobin-Sickle Cell Disease Syndrome
Hereditary Persistence of Fetal Hemoglobin-Beta-Thalassemia Syndrome
Sickle Cell-Hemoglobin E Disease Syndrome
Sickle Cell-Hemoglobin D Disease Syndrome
Alpha-Thalassemia
Hemolytic Anemia
Hemoglobin M Disease
Autosomal Dominant Secondary Polycythemia
Thalassemia
Hemoglobin Lepore-Beta-Thalassemia Syndrome
Fetal Hemoglobin Quantitative Trait Locus 1
Thalassemia
Sickle Cell Disease
Beta-Thalassemia, Dominant Inclusion Body Type
Fetal Hemoglobin Quantitative Trait Locus 1
Beta-Thalassemia
Heinz Body Anemias
Erythrocytosis, Familial, 6
Methemoglobinemia, Beta Type
Beta-Thalassemia Intermedia
Beta-Thalassemia Major
Hemoglobin C Disease
Hemoglobin E Disease
Hemoglobin E-Beta-Thalassemia Syndrome
Sickle Cell-Hemoglobin C Disease Syndrome
Hemoglobin D Disease
Malaria
Hemoglobinopathy
Deficiency Anemia
Hemoglobin Se Disease
Sickle Cell Disease and Related Diseases
Congenital Methemoglobinemia
Hemoglobin C-Beta-Thalassemia Syndrome
Sickle Cell-Beta-Thalassemia Disease Syndrome
Hemoglobin Lepore-Beta-Thalassemia Syndrome
Hereditary Persistence of Fetal Hemoglobin-Sickle Cell Disease Syndrome
Hereditary Persistence of Fetal Hemoglobin-Beta-Thalassemia Syndrome
Sickle Cell-Hemoglobin E Disease Syndrome
Sickle Cell-Hemoglobin D Disease Syndrome
Alpha-Thalassemia
Hemolytic Anemia
Hemoglobin M Disease
Autosomal Dominant Secondary Polycythemia
Thalassemia
应用领域
β地中海贫血
