智鼠故事 
B6-Fgfr3*Y367C 小鼠
复苏/繁育服务
其他模型
* 使用本品系发表的文献需注明：B6-Fgfr3*Y367C 小鼠 mice (Catalog C001745) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
只
品系描述
B6-Fgfr3*Y367C小鼠是通过基因编辑技术在小鼠Fgfr3基因中引入Y367C突变而获得。内部初步数据显示，纯合B6-Fgfr3*Y367C小鼠在3周龄时出现死亡。该模型可用于软骨发育不全（ACH）、致死性发育不良（TD）等疾病机制及治疗手段研究。
相关疾病：
Achondroplasia
Hypochondroplasia
Muenke Syndrome
Thanatophoric Dysplasia, Type I
Crouzon Syndrome with Acanthosis Nigricans
Achondroplasia, Severe, with Developmental Delay and Acanthosis Nigricans
Thanatophoric Dysplasia, Type Ii
Cervical Cancer
Nevus, Epidermal
Bladder Cancer
Camptodactyly, Tall Stature, and Hearing Loss Syndrome
Testicular Germ Cell Tumor
Camptodactyly-Tall Stature-Scoliosis-Hearing Loss Syndrome
Keratosis, Seborrheic
Lacrimoauriculodentodigital Syndrome 2
Lacrimoauriculodentodigital Syndrome 1
Spermatocytoma
Fgfr3-Related Chondrodysplasia
Testicular Germ Cell Cancer
Non-Syndromic Bicoronal Craniosynostosis
Crouzon Syndrome
Osteochondrodysplasia
Testicular Cancer
Cervix Carcinoma
Hemifacial Hyperplasia
Childhood Absence Epilepsy
Saethre-Chotzen Syndrome
Craniosynostosis
Colorectal Cancer
Plasma Cell Neoplasm
Larsen Syndrome
Renal Hypodysplasia/aplasia 3
Myeloma, Multiple
Giant Cell Glioblastoma
Gliosarcoma
Primary Bone Dysplasia
Connective Tissue Disease
Nervous System Disease
Congenital Nervous System Abnormality
Acanthosis Nigricans
Bladder Urothelial Carcinoma
46,xy Disorder of Sex Development
Lung Squamous Cell Carcinoma
Hepatoblastoma
Myeloproliferative Neoplasm
Renal Cell Carcinoma, Papillary, 1
Lung Cancer
Squamous Cell Carcinoma, Head and Neck
Lung Cancer Susceptibility 3
应用领域
软骨发育不全（ACH）、致死性发育不良（TD）等疾病机制及治疗手段研究
Fgfr3 Y367C突变拮抗剂研究
