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C-NKG-MHC dKO (H2-K1/H2-Ab1/H2-D1) 小鼠
复苏/繁育服务
产品名称:
C-NKG-MHC dKO (H2-K1/H2-Ab1/H2-D1) 小鼠
产品编号:
C001705
品系背景:
C-NKG
重度免疫缺陷鼠
* 使用本品系发表的文献需注明:C-NKG-MHC dKO (H2-K1/H2-Ab1/H2-D1) 小鼠 mice (Catalog C001705) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
品系描述
C-NKG-MHC dKO (H2-K1/H2-Ab1/H2-D1) 小鼠通过靶向敲除关键的MHC I类分子(H2-K1、H2-D1)和Ⅱ类分子(H2-Ab1)构建而成,能够有效规避引发GvHD的免疫不匹配问题。这种策略性敲除显著延迟了GvHD的发生,为PBMC植入后人类免疫系统重建的长期体内观察提供了支持。该模型为纵向研究人源免疫细胞的功能及小鼠宿主体内的跨物种免疫动态提供了有力的研究平台。
相关疾病:
Asthma
Nasopharyngeal Carcinoma
Choriocarcinoma
Human Cytomegalovirus Infection
Glaucomatocyclitic Crisis
Ceftazidime Allergy
Nk Cell Deficiency
Parotid Gland Adenoid Cystic Carcinoma
Bare Lymphocyte Syndrome, Type I
Myeloma, Multiple
Celiac Disease 1
Leukemia, Acute Myeloid
Psoriasis 1
Human Immunodeficiency Virus Type 1
B-Lymphoblastic Leukemia/lymphoma with T(9;22)(q34.1;q11.2)
Severe Cutaneous Adverse Reaction
Spondyloarthropathy 1
Takayasu Arteritis
Reactive Arthritis
Erythema Multiforme Major
Ankylosing Spondylitis 1
Pulmonary Arterial Hypertension Associated with Connective Tissue Disease
Temporal Arteritis
Behcet Syndrome
Severe Cutaneous Adverse Reaction
Birdshot Chorioretinopathy
Celiac Disease 1
Creutzfeldt-Jakob Disease
Multiple Sclerosis
Bullous Pemphigoid
Pediatric Multiple Sclerosis
Narcolepsy 1
Narcolepsy 2
Idiopathic Achalasia
Asthma
Nasopharyngeal Carcinoma
Choriocarcinoma
Human Cytomegalovirus Infection
Glaucomatocyclitic Crisis
Ceftazidime Allergy
Nk Cell Deficiency
Parotid Gland Adenoid Cystic Carcinoma
Bare Lymphocyte Syndrome, Type I
Myeloma, Multiple
Celiac Disease 1
Leukemia, Acute Myeloid
Psoriasis 1
Human Immunodeficiency Virus Type 1
B-Lymphoblastic Leukemia/lymphoma with T(9;22)(q34.1;q11.2)
Severe Cutaneous Adverse Reaction
Spondyloarthropathy 1
Takayasu Arteritis
Reactive Arthritis
Erythema Multiforme Major
Ankylosing Spondylitis 1
Pulmonary Arterial Hypertension Associated with Connective Tissue Disease
Temporal Arteritis
Behcet Syndrome
Severe Cutaneous Adverse Reaction
Birdshot Chorioretinopathy
应用领域
构建免疫系统人源化小鼠模型
异种移植物抗宿主病(GvHD)研究
免疫系统、造血系统和血液疾病研究
人源细胞系异种移植(CDX)及药物筛选和药效评价
患者肿瘤组织异种移植(PDX)及药物筛选和药效评价
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