智鼠故事 
Pvalb-T2A-iCre 小鼠
复苏/繁育服务
产品名称：
Pvalb-T2A-iCre 小鼠
产品编号：
C001589
品系背景：
C57BL/6JCya
表达组织/细胞举例：
表达 Parvalbumin 蛋白的神经元
* 使用本品系发表的文献需注明：Pvalb-T2A-iCre 小鼠 mice (Catalog C001589) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
只
基本信息
产品名称
Pvalb-T2A-iCre 小鼠
产品编号
C001589
基因名
品系背景
C57BL/6JCya
基因别称
PV；Pva；Parv
模型分类
Cre工具鼠
NCBI ID
小鼠表型
染色体
15
更多信息
* 使用本品系发表的文献需注明：Pvalb-T2A-iCre 小鼠 mice (Catalog C001589) were purchased from Cyagen.
品系描述
Pvalb-T2A-iCre 小鼠是通过基因编辑技术将 T2A-iCre 表达组件整合到小鼠内源 Pvalb 基因的终止密码子处获得的，在小鼠 Pvalb 基因调控元件的驱动下表达 iCre 重组酶（密码子优化后的 Cre 重组酶）。iCre 重组酶的表达模式与内源 Pvalb 基因相似，该策略不影响小鼠内源 Pvalb 基因的表达。利用 2A 肽进行连接可以避免多基因表达过程中蛋白活性低和下游基因表达低的缺点。当 Pvalb-T2A-iCre 小鼠与含有 loxP 位点的小鼠杂交时，可在子代表达 Parvalbumin 蛋白的神经元中引发由 Cre 重组酶介导的 loxP 位点间的序列重组。
相关疾病：
Fetal Alcohol Syndrome
Temporal Lobe Epilepsy
Fish Allergy
Oncocytoma
Food Allergy
Spinocerebellar Ataxia 1
Ganglioglioma
Status Epilepticus
Scrapie
Motor Neuron Disease
Creutzfeldt-Jakob Disease
Major Depressive Disorder
Epilepsy
Renal Pelvis Squamous Cell Carcinoma
Schizophrenia
Crustacean Allergy
Articulation Disorder
Breast Fibrosarcoma
Tic Disorder
Tuberous Sclerosis
Apple Allergy
Supranuclear Palsy, Progressive, 1
Transient Cerebral Ischemia
Fetal Alcohol Spectrum Disorder
Amblyopia
Renal Cell Carcinoma, Nonpapillary
Hypoxic Ischemic Encephalopathy
Pervasive Developmental Disorder
Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type
Speech Disorder
Focal Epilepsy
Epithelial-Stromal Tgfbi Dystrophy
Wernicke-Korsakoff Syndrome
Crab Allergy
Lattice Corneal Dystrophy
Disease of Mental Health
Specific Developmental Disorder
Psychotic Disorder
Childhood Electroclinical Syndrome
Amyotrophic Lateral Sclerosis 1
Stuttering
Dravet Syndrome
Childhood Absence Epilepsy
Dystonia
Renal Oncocytoma
Fragile X Syndrome
Post-Traumatic Stress Disorder
Corneal Dystrophy, Fleck
Melon Allergy
Alzheimer Disease, Familial, 1
Flying Phobia
Gilles De La Tourette Syndrome
Orange Allergy
Schizophrenia 12
Generalized Epilepsy with Febrile Seizures Plus
Syndromic X-Linked Intellectual Disability
Hypertrophic Cardiomyopathy
Chromosome 22q11.2 Deletion Syndrome, Distal
Epilepsy, Idiopathic Generalized
Syndromic Intellectual Disability
Epilepsy, Myoclonic Juvenile
Attention Deficit-Hyperactivity Disorder
Rett Syndrome
Choreatic Disease
Movement Disease
Developmental and Epileptic Encephalopathy
West Syndrome
Parkinson Disease, Late-Onset
Huntington Disease
Nervous System Disease
Congenital Nervous System Abnormality
Microcephaly
