智鼠故事 
Acod1-KO 基因敲除小鼠
纯合子现货秒杀
复苏/繁育服务
产品名称
Acod1-KO 基因敲除小鼠
产品编号
S-KO-02679
品系全称
C57BL/6NCya-Acod1em1/Cya
品系背景
C57BL/6NCya
品系编号
KOCMP-16365-Acod1-B6N-VA
品系状态
使用本品系发表的文献需注明： Acod1-KO 基因敲除小鼠 mice (Strain S-KO-02679) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因全称
aconitate decarboxylase 1
基因别称
CAD，Irg1
染色体号
Chr 14 (Mouse)
NCBI ID
转录本 ID
NCBI: NM_008392 | Ensembl: ENSMUST00000022722
修饰方式
全身性基因敲除
靶向范围
Exon 2~4
敲除长度
~3.3 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:103206LPS-stimulated bone marrow macrophages derived from homozygous null mice fail to produce itaconate and exhibit significantly decreased succinate accumulation.
发表文献
Cellular & Molecular Immunology
2024-05-14
Neutrophil-macrophage communication via extracellularvesicle transfer promotes itaconate accumulation andameliorates cytokine storm syndrome
Clinical Immunology
2024-04
LXA4 protected mice from renal ischemia/reperfusion injury by promoting IRG1/Nrf2 and IRAK-M-TRAF6 signal pathways
European Journal of Inflammation
2024-03-20
Irg1/itaconate activates Nrf2/HO-1 pathway and mitigates septic liver injury in mice
Preprint
2023-09-11
Immune-response gene 1 deficiency aggravates inflammation-triggered cardiac dysfunction by inducing M1 macrophage polarization and aggravating Ly6C high monocyte recruitment
Cell Death & Disease
2023-07-30
Negative regulation of pro-apoptotic AMPK/JNK pathway by itaconate in mice with fulminant liver injury
Genes & Diseases
2022-05-30
Protective effects of IRG1/itaconate on acute colitis through the inhibition of gasdermins-mediated pyroptosis and inflammation response
1
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