Fxr1-KO 基因敲除小鼠

1. Kang, Jun-Yan, Wen, Ze, Pan, Duo, Huang, Ying, Liu, Mo-Fang. 2022. LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs. In Science (New York, N.Y.), 377, eabj6647. doi:10.1126/science.abj6647. https://pubmed.ncbi.nlm.nih.gov/35951695/

2. Vijayakumar, Anitha, Majumder, Mrinmoyee, Yin, Shasha, Gan, Wenjian, Palanisamy, Viswanathan. . PRMT5-mediated arginine methylation of FXR1 is essential for RNA binding in cancer cells. In Nucleic acids research, 52, 7225-7244. doi:10.1093/nar/gkae319. https://pubmed.ncbi.nlm.nih.gov/38709899/

3. George, Jasmine, Li, Yongsheng, Kadamberi, Ishaque P, Pradeep, Sunila, Chaluvally-Raghavan, Pradeep. . RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site. In Cell reports, 37, 109934. doi:10.1016/j.celrep.2021.109934. https://pubmed.ncbi.nlm.nih.gov/34731628/

4. Zhou, Gui-Feng, Tang, Jing, Ma, Yuan-Lin, Deng, Xiao-Juan, Chen, Guo-Jun. 2023. ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation. In Proceedings of the National Academy of Sciences of the United States of America, 120, e2220148120. doi:10.1073/pnas.2220148120. https://pubmed.ncbi.nlm.nih.gov/37216506/

5. Deng, Shuang, Zhang, Jialiang, Su, Jiachun, Chen, Jianjun, Zheng, Jian. 2022. RNA m6A regulates transcription via DNA demethylation and chromatin accessibility. In Nature genetics, 54, 1427-1437. doi:10.1038/s41588-022-01173-1. https://pubmed.ncbi.nlm.nih.gov/36071173/