Serpind1-KO 基因敲除小鼠

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产品名称

Serpind1-KO 基因敲除小鼠

产品编号

S-KO-20234

品系全称

C57BL/6JCya-Serpind1em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-15160-Serpind1-B6J-VC

品系状态

使用本品系发表的文献需注明: Serpind1-KO 基因敲除小鼠 mice (Strain S-KO-20234) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
serine (or cysteine) peptidase inhibitor, clade D, member 1
基因别称
HC-II,HCII,Hcf2
染色体号
Chr 16 (Mouse)
转录本 ID
NCBI: NM_008223 | Ensembl: ENSMUST00000023450
修饰方式
全身性基因敲除
靶向范围
Exon 3~5
敲除长度
~4.7 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:96051Mice homozygous for disruptions in this gene display a normal phenotype.
Serpind1,也称为Heparin cofactor II (HCII),是一种重要的丝氨酸蛋白酶抑制剂。Serpind1主要在肝脏中表达,并在血液凝固和抗凝系统中发挥重要作用。它通过与凝血酶结合,抑制其活性,从而在维持血液凝固平衡中发挥关键作用。此外,Serpind1还参与调节炎症反应和免疫应答,并与多种疾病的发生和发展密切相关。

在参考文献中,Serpind1的表达与多种癌症的发生和发展相关。例如,在子宫内膜癌中,Serpind1的表达与肿瘤的微卫星稳定性、分级、分期、组织学类型和患者年龄等临床病理特征相关[1]。Serpind1在子宫内膜癌中的表达与免疫浸润水平相关,提示其可能作为免疫治疗的潜在靶点。在肺腺癌中,Serpind1被确定为预后相关基因,其高表达与患者的不良预后相关[2]。此外,Serpind1还与甲状腺癌、卵巢癌、肺鳞状细胞癌等多种癌症的发生和发展相关[4][7][9]。

除了在癌症中的重要作用,Serpind1还与炎症性疾病的发生和发展相关。例如,在坏死性小肠结肠炎中,Serpind1的表达显著下调,提示其可能参与该疾病的凝血和抗凝系统紊乱[3]。在抑郁症中,Serpind1的表达水平升高,可能与炎症反应和急性相反应相关[6]。此外,Serpind1还与动脉粥样硬化、糖尿病心肌病等心血管疾病的发生和发展相关[5][8]。

综上所述,Serpind1是一种重要的丝氨酸蛋白酶抑制剂,在血液凝固和抗凝系统中发挥重要作用。Serpind1的表达与多种癌症、炎症性疾病和心血管疾病的发生和发展相关,提示其可能作为这些疾病的诊断和治疗的潜在靶点。未来研究需要进一步探讨Serpind1在疾病发生和发展中的具体作用机制,以及其作为疾病诊断和治疗的潜在价值。

参考文献:
1. Xiao, Yunyun, Yu, XiaoChuan, Wang, Yaping, Wang, Daqing, Wang, Huali. 2024. A novel immune-related gene signature for diagnosis and potential immunotherapy of microsatellite stable endometrial carcinoma. In Scientific reports, 14, 3738. doi:10.1038/s41598-024-53338-z. https://pubmed.ncbi.nlm.nih.gov/38355782/
2. Guo, Zehuai, Qi, Xiangjun, Li, Zeyun, Chen, Ming, Cao, Yang. 2023. Development and validation of an immune-related gene signature for prognosis in Lung adenocarcinoma. In IET systems biology, 17, 27-38. doi:10.1049/syb2.12057. https://pubmed.ncbi.nlm.nih.gov/36728032/
3. Giuliani, Stefano, Tan, Yew-Wei, Zheng, Dongling, Kennea, Nigel, Jamshidi, Yalda. . Coagulation Gene Expression Profiling in Infants With Necrotizing Enterocolitis. In Journal of pediatric gastroenterology and nutrition, 63, e169-e175. doi:. https://pubmed.ncbi.nlm.nih.gov/27050058/
4. Li, Xiang, Ding, Zigang, Tong, Yun. 2024. Identification of SUMOylation-related biomarkers in papillary thyroid carcinoma. In Cancer cell international, 24, 149. doi:10.1186/s12935-024-03323-3. https://pubmed.ncbi.nlm.nih.gov/38671425/
5. He, Xiao-Nan, Xin, Jin-Yuan, Zhan, Jin-Liang, Zhang, Xiao-Ling, Bai, Ying-Chen. 2021. Polycyclic aromatic hydrocarbons induce endothelial injury through miR-155 to promote atherosclerosis. In Environmental and molecular mutagenesis, 62, 409-421. doi:10.1002/em.22454. https://pubmed.ncbi.nlm.nih.gov/34331478/
6. Wang, Qi, Yu, Chunyue, Shi, Shanshan, Jiang, Wenhai, Wei, Taiming. 2018. An analysis of plasma reveals proteins in the acute phase response pathway to be candidate diagnostic biomarkers for depression. In Psychiatry research, 272, 404-410. doi:10.1016/j.psychres.2018.11.069. https://pubmed.ncbi.nlm.nih.gov/30611956/
7. Zhu, Liancheng, Guo, Qian, Jin, Shan, Li, Xiao, Lin, Bei. 2016. Analysis of the gene expression profile in response to human epididymis protein 4 in epithelial ovarian cancer cells. In Oncology reports, 36, 1592-604. doi:10.3892/or.2016.4926. https://pubmed.ncbi.nlm.nih.gov/27430660/
8. Pei, Jie, Song, Rende, Bao, Pengjia, Guo, Xian, Yan, Ping. 2022. Differential proteomic analysis demonstrates follicle fluid participate immune reaction and protein translation in yak. In BMC veterinary research, 18, 34. doi:10.1186/s12917-021-03097-0. https://pubmed.ncbi.nlm.nih.gov/35031034/
9. Ma, Hongxia, Tong, Lihong, Zhang, Qian, Chang, Wenjun, Li, Fengsen. 2020. Identification of 5 Gene Signatures in Survival Prediction for Patients with Lung Squamous Cell Carcinoma Based on Integrated Multiomics Data Analysis. In BioMed research international, 2020, 6427483. doi:10.1155/2020/6427483. https://pubmed.ncbi.nlm.nih.gov/32596344/