智鼠故事 
Thbs4-KO 基因敲除小鼠
复苏/繁育服务
产品名称
Thbs4-KO 基因敲除小鼠
产品编号
S-KO-19889
品系全称
C57BL/6JCya-Thbs4em1/Cya
品系背景
C57BL/6JCya
品系编号
KOCMP-21828-Thbs4-B6J-VB
品系状态
使用本品系发表的文献需注明： Thbs4-KO 基因敲除小鼠 mice (Strain S-KO-19889) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因别称
TSP4
NCBI ID
染色体号
Chr 13
NCBI RefSeq
NM_011582
Ensembl ID
ENSMUST00000022213
修饰方式
全身性基因敲除
靶向范围
Exon 5~8
敲除长度
~3.1 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:1101779Mice homozygous for a targeted allele exhibit increased sensitivity to cardiac pressure overload, including increased hypertrophy, decreased ejection fraction, decreased microvessel number, increased extracellular matrix deposition and increased fibrosis. Homozygous KO leads to impaired wound healing and delayed retinal vasculature development and affects macrophage differentiation. Homozygosity for the p.A389P mutation leads to enhanced wound healing and accelerated retinal vasculature development and affects macrophage differentiation.
