Pkn1-KO 基因敲除小鼠

1. Siddique, Salman Mahmud, Kubouchi, Koji, Shinmichi, Yuka, Itoh, Tomoo, Mukai, Hideyuki. 2019. PKN1 kinase-negative knock-in mice develop splenomegaly and leukopenia at advanced age without obvious autoimmune-like phenotypes. In Scientific reports, 9, 13977. doi:10.1038/s41598-019-50419-2. https://pubmed.ncbi.nlm.nih.gov/31562379/

2. Zhu, Xiaoli, Li, Mingrui, Jia, Xiang, Wang, Gang, Wang, Jingqiang. 2019. The homeoprotein Msx1 cooperates with Pkn1 to prevent terminal differentiation in myogenic precursor cells. In Biochimie, 162, 55-65. doi:10.1016/j.biochi.2019.04.003. https://pubmed.ncbi.nlm.nih.gov/30959082/

3. Willems, Alex, Liang, Yuanke, Heyman, Jefri, Vandepoele, Klaas, De Veylder, Lieven. . Plant lineage-specific PIKMIN1 drives APC/CCCS52A2 E3-ligase activity-dependent cell division. In Plant physiology, 191, 1574-1595. doi:10.1093/plphys/kiac528. https://pubmed.ncbi.nlm.nih.gov/36423220/

4. Jin, Young-June, Liang, Guozheng, Li, Rui, Wettschureck, Nina, Offermanns, Stefan. 2025. Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression. In Nature cardiovascular research, 4, 180-196. doi:10.1038/s44161-024-00593-y. https://pubmed.ncbi.nlm.nih.gov/39779823/

5. Yasuda, Hiroki, Yamamoto, Hikaru, Hanamura, Kenji, Ono, Yoshitaka, Mukai, Hideyuki. 2020. PKN1 promotes synapse maturation by inhibiting mGluR-dependent silencing through neuronal glutamate transporter activation. In Communications biology, 3, 710. doi:10.1038/s42003-020-01435-w. https://pubmed.ncbi.nlm.nih.gov/33244074/