Fkbp4-KO 基因敲除小鼠

下单100%中奖,最高可得千元京东卡
复苏/繁育服务
产品名称

Fkbp4-KO 基因敲除小鼠

产品编号

S-KO-18819

品系全称

C57BL/6JCya-Fkbp4em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-14228-Fkbp4-B6J-VA

品系状态

使用本品系发表的文献需注明: Fkbp4-KO 基因敲除小鼠 mice (Strain S-KO-18819) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
FK506 binding protein 4
基因别称
FKBP-4,FKBP-52,FKBP52,FKPB52,p59
染色体号
Chr 6 (Mouse)
转录本 ID
NCBI: NM_010219 | Ensembl: ENSMUST00000032508
修饰方式
全身性基因敲除
靶向范围
Exon 4~5
敲除长度
~1.4 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:95543Homozygous null males show reproductive tissue defects consistent with androgen insensitivity such as ambiguous external genitalia, dysgenic prostate, malformed seminal gland and cryptorchism. Males also exhibit hypospadia and infertility. Females are sterile due to failure of implantation.
FKBP4(FK506结合蛋白4)是一种免疫亲素蛋白,属于FK506结合蛋白家族。FKBP4是一种可溶性蛋白质,与FK506(一种免疫抑制剂)和免疫抑制剂他克莫司(FK506)结合,调节免疫系统的功能。FKBP4在免疫系统中发挥重要作用,参与免疫调节、细胞凋亡和细胞周期调控等生物学过程。FKBP4还与多种疾病的发生和发展密切相关,包括自身免疫性疾病、肿瘤和神经退行性疾病等。

FKBP4在自身免疫性疾病中发挥重要作用。例如,在系统性红斑狼疮(SLE)患者中,FKBP4基因多态性与疾病易感性、糖皮质激素疗效、焦虑、抑郁和与健康相关的生活质量(HRQOL)相关。FKBP5基因多态性与SLE患者的抑郁和糖皮质激素疗效相关,而FKBP4和FKBP5基因多态性与SLE患者的HRQOL改善相关[1]。

FKBP4在肿瘤发生和发展中也发挥重要作用。例如,FKBP4在肝细胞癌(HCC)组织中上调,并与患者预后不良相关。FKBP4通过p53/HK2信号通路促进HCC发展和糖酵解。此外,FKBP4在乳腺癌、骨肉瘤和非小细胞肺癌(NSCLC)等多种癌症中上调,并与患者预后不良相关[2,3,4,5,6,8]。

FKBP4还与神经退行性疾病的发生和发展相关。例如,FKBP4在帕金森病(PD)患者脑脊液(CSF)和诱导多能干细胞(iPSC)中下调。FKBP4与GBA1基因突变相关的PD患者CSF中的代谢相关蛋白水平显著改变[7]。

FKBP4是一种重要的免疫亲素蛋白,在免疫调节、细胞凋亡和细胞周期调控等生物学过程中发挥重要作用。FKBP4在自身免疫性疾病、肿瘤和神经退行性疾病等疾病的发生和发展中发挥重要作用。FKBP4的研究有助于深入理解免疫亲素蛋白的生物学功能和疾病发生机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Lou, Qiu-Yue, Li, Zhen, Teng, Ying, Hu, Wen-Biao, Zou, Yan-Feng. 2020. Associations of FKBP4 and FKBP5 gene polymorphisms with disease susceptibility, glucocorticoid efficacy, anxiety, depression, and health-related quality of life in systemic lupus erythematosus patients. In Clinical rheumatology, 40, 167-179. doi:10.1007/s10067-020-05195-0. https://pubmed.ncbi.nlm.nih.gov/32557257/
2. Ilaslan, Erkut, Markosyan, Renata, Sproll, Patrick, Jaruzelska, Jadwiga, Kusz-Zamelczyk, Kamila. 2020. The FKBP4 Gene, Encoding a Regulator of the Androgen Receptor Signaling Pathway, Is a Novel Candidate Gene for Androgen Insensitivity Syndrome. In International journal of molecular sciences, 21, . doi:10.3390/ijms21218403. https://pubmed.ncbi.nlm.nih.gov/33182400/
3. Kageyama, Kazunori, Iwasaki, Yasumasa, Watanuki, Yutaka, Niioka, Kanako, Daimon, Makoto. 2021. Differential Effects of Fkbp4 and Fkbp5 on Regulation of the Proopiomelanocortin Gene in Murine AtT-20 Corticotroph Cells. In International journal of molecular sciences, 22, . doi:10.3390/ijms22115724. https://pubmed.ncbi.nlm.nih.gov/34072036/
4. Zeng, Zhenzhen, Xu, Shasha, Wang, Ruihua, Han, Xingmin. 2024. FKBP4 promotes glycolysis and hepatocellular carcinoma progression via p53/HK2 axis. In Scientific reports, 14, 26893. doi:10.1038/s41598-024-78383-6. https://pubmed.ncbi.nlm.nih.gov/39505995/
5. Xiong, Hanchu, Chen, Zihan, Zheng, Wenwen, Yu, Xiao-Fang, Zhou, Jichun. 2020. FKBP4 is a malignant indicator in luminal A subtype of breast cancer. In Journal of Cancer, 11, 1727-1736. doi:10.7150/jca.40982. https://pubmed.ncbi.nlm.nih.gov/32194784/
6. Niforou, Katerina M, Anagnostopoulos, Athanasios K, Vougas, Konstantinos, Gorgoulis, Vassilis G, Tsangaris, George T. . The proteome profile of the human osteosarcoma U2OS cell line. In Cancer genomics & proteomics, 5, 63-78. doi:. https://pubmed.ncbi.nlm.nih.gov/18359981/
7. Kojima, Rika, Paslawski, Wojciech, Lyu, Guochang, Zhang, Xiaoqun, Svenningsson, Per. 2024. Secretome Analyses Identify FKBP4 as a GBA1-Associated Protein in CSF and iPS Cells from Parkinson's Disease Patients with GBA1 Mutations. In International journal of molecular sciences, 25, . doi:10.3390/ijms25010683. https://pubmed.ncbi.nlm.nih.gov/38203854/
8. Meng, Wen, Meng, Jingfei, Jiang, Hong, Wei, Dongshan, Ding, Qingsong. 2020. FKBP4 Accelerates Malignant Progression of Non-Small-Cell Lung Cancer by Activating the Akt/mTOR Signaling Pathway. In Analytical cellular pathology (Amsterdam), 2020, 6021602. doi:10.1155/2020/6021602. https://pubmed.ncbi.nlm.nih.gov/33354489/