Dpyd-KO 基因敲除小鼠

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2. Henricks, Linda M, Lunenburg, Carin A T C, Meulendijks, Didier, Schellens, Jan H M, Guchelaar, Henk-Jan. 2015. Translating DPYD genotype into DPD phenotype: using the DPYD gene activity score. In Pharmacogenomics, 16, 1277-86. doi:10.2217/pgs.15.70. https://pubmed.ncbi.nlm.nih.gov/26265346/

3. White, Cassandra, Scott, Rodney J, Paul, Christine, Mossman, David, Ackland, Stephen. 2021. Ethnic Diversity of DPD Activity and the DPYD Gene: Review of the Literature. In Pharmacogenomics and personalized medicine, 14, 1603-1617. doi:10.2147/PGPM.S337147. https://pubmed.ncbi.nlm.nih.gov/34916829/

4. Henricks, Linda M, Lunenburg, Carin A T C, de Man, Femke M, Guchelaar, Henk-Jan, Schellens, Jan H M. 2018. DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis. In The Lancet. Oncology, 19, 1459-1467. doi:10.1016/S1470-2045(18)30686-7. https://pubmed.ncbi.nlm.nih.gov/30348537/

5. Turner, Amy J, Haidar, Cyrine E, Yang, Wenjian, Broeckel, Ulrich, Gaedigk, Andrea. . Updated DPYD HapB3 haplotype structure and implications for pharmacogenomic testing. In Clinical and translational science, 17, e13699. doi:10.1111/cts.13699. https://pubmed.ncbi.nlm.nih.gov/38129972/

6. Knikman, Jonathan E, Wilting, Tycho A, Lopez-Yurda, Marta, Guchelaar, Henk-Jan, Cats, Annemieke. 2023. Survival of Patients With Cancer With DPYD Variant Alleles and Dose-Individualized Fluoropyrimidine Therapy-A Matched-Pair Analysis. In Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 41, 5411-5421. doi:10.1200/JCO.22.02780. https://pubmed.ncbi.nlm.nih.gov/37639651/

7. Botton, Mariana Rodrigues, Hentschke-Lopes, Marina, Matte, Ursula. 2021. Frequency of DPYD gene variants and phenotype inference in a Southern Brazilian population. In Annals of human genetics, 86, 102-107. doi:10.1111/ahg.12453. https://pubmed.ncbi.nlm.nih.gov/34897655/

8. Ikonnikova, Anna, Fedorinov, Denis, Gryadunov, Dmitry, Emelyanova, Marina, Lyadov, Vladimir. 2024. MIR27A Gene Polymorphism Modifies the Effect of Common DPYD Gene Variants on Severe Toxicity in Patients with Gastrointestinal Tumors Treated with Fluoropyrimidine-Based Anticancer Therapy. In International journal of molecular sciences, 25, . doi:10.3390/ijms25158503. https://pubmed.ncbi.nlm.nih.gov/39126072/