Gucy2d-KO 基因敲除小鼠

1. McCullough, K Tyler, Boye, Sanford L, Fajardo, Diego, Maeder, Morgan L, Boye, Shannon E. 2018. Somatic Gene Editing of GUCY2D by AAV-CRISPR/Cas9 Alters Retinal Structure and Function in Mouse and Macaque. In Human gene therapy, 30, 571-589. doi:10.1089/hum.2018.193. https://pubmed.ncbi.nlm.nih.gov/30358434/

2. Sharon, Dror, Wimberg, Hanna, Kinarty, Yael, Koch, Karl-Wilhelm. 2017. Genotype-functional-phenotype correlations in photoreceptor guanylate cyclase (GC-E) encoded by GUCY2D. In Progress in retinal and eye research, 63, 69-91. doi:10.1016/j.preteyeres.2017.10.003. https://pubmed.ncbi.nlm.nih.gov/29061346/

3. Jacobson, Samuel G, Cideciyan, Artur V, Ho, Allen C, Dizhoor, Alexander M, Boye, Shannon E. 2021. Safety and improved efficacy signals following gene therapy in childhood blindness caused by GUCY2D mutations. In iScience, 24, 102409. doi:10.1016/j.isci.2021.102409. https://pubmed.ncbi.nlm.nih.gov/33997691/