Ncoa2-KO 基因敲除小鼠

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产品名称

Ncoa2-KO 基因敲除小鼠

产品编号

S-KO-17815

品系全称

C57BL/6JCya-Ncoa2em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-17978-Ncoa2-B6J-VA

品系状态

使用本品系发表的文献需注明: Ncoa2-KO 基因敲除小鼠 mice (Strain S-KO-17815) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
nuclear receptor coactivator 2
基因别称
D1Ertd433e,GRIP-1,Grip1,KAT13C,NCoA-2,SRC-2,TIF2,bHLHe75
染色体号
Chr 1 (Mouse)
转录本 ID
NCBI: NM_008678.3 | Ensembl: ENSMUST00000006037
修饰方式
全身性基因敲除
靶向范围
Exon 4
敲除长度
~1.3 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:1276533Homozygous null mice exhibit a transient postnatal growth deficiency and hypofertility. Male hypofertility is due to defects in spermiogenesis and an age-dependent testicular degeneration preceded by defective lipid metabolism in Sertoli cells. Female hypofertility is due to a placental hypoplasia.
NCOA2,即核受体共激活因子2,是一种重要的转录共激活因子,参与多种生物学过程,包括细胞增殖、分化、代谢和疾病发生。NCOA2与多种核受体相互作用,如雌激素受体、雄激素受体、糖皮质激素受体等,调节基因表达和信号通路。此外,NCOA2还与多种非核受体蛋白相互作用,参与细胞骨架重塑、细胞粘附和迁移等过程。NCOA2的异常表达和功能改变与多种疾病的发生发展密切相关,包括癌症、肥胖、血脂异常等。

在前列腺癌中,NCOA2的基因扩增和过表达与疾病进展和不良预后相关[1]。NCOA2的基因扩增和过表达与前列腺癌的风险分层和预后评估相关[4]。此外,NCOA2的基因融合,如VGLL2-NCOA2,也与儿童横纹肌肉瘤的发生发展相关[2]。NCOA2的基因多态性与肥胖和血脂异常相关[3]。NCOA2的基因融合,如PAX3-NCOA2,与横纹肌肉瘤的增殖和分化相关[5]。NCOA2的基因融合,如HEY1-NCOA2,与软骨肉瘤的发生发展相关[6]。NCOA2的基因融合,如WWTR1-NCOA2,与唾液腺肿瘤的发生发展相关[7]。

NCOA2的基因融合,如EWSR1-NCOA2和FUS-TFCP2,与圆形细胞肉瘤的发生发展相关[8]。GTF2I基因突变与胸腺上皮肿瘤的发生发展相关,GTF2I与NCOA2的基因融合也与软组织血管纤维瘤的发生发展相关[9]。

综上所述,NCOA2是一种重要的转录共激活因子,参与多种生物学过程,包括细胞增殖、分化、代谢和疾病发生。NCOA2的异常表达和功能改变与多种疾病的发生发展密切相关,包括癌症、肥胖、血脂异常等。NCOA2的研究有助于深入理解转录共激活因子的生物学功能和疾病发生机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Taylor, Barry S, Schultz, Nikolaus, Hieronymus, Haley, Sawyers, Charles L, Gerald, William L. 2010. Integrative genomic profiling of human prostate cancer. In Cancer cell, 18, 11-22. doi:10.1016/j.ccr.2010.05.026. https://pubmed.ncbi.nlm.nih.gov/20579941/
2. Watson, Sarah, LaVigne, Collette A, Xu, Lin, Amatruda, James F, Kendall, Genevieve C. 2023. VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis. In Cell reports, 42, 112013. doi:10.1016/j.celrep.2023.112013. https://pubmed.ncbi.nlm.nih.gov/36656711/
3. Lu, Yuping, Habtetsion, Tsadik Ghebreamlak, Li, Yong, Cheng, Yi, Liu, Yawen. 2015. Association of NCOA2 gene polymorphisms with obesity and dyslipidemia in the Chinese Han population. In International journal of clinical and experimental pathology, 8, 7341-9. doi:. https://pubmed.ncbi.nlm.nih.gov/26261634/
4. Silva, Maria P, Barros-Silva, João D, Vieira, Joana, Paulo, Paula, Teixeira, Manuel R. 2016. NCOA2 is a candidate target gene of 8q gain associated with clinically aggressive prostate cancer. In Genes, chromosomes & cancer, 55, 365-74. doi:10.1002/gcc.22340. https://pubmed.ncbi.nlm.nih.gov/26799514/
5. Yoshida, H, Miyachi, M, Sakamoto, K, Hojo, H, Hosoi, H. 2013. PAX3-NCOA2 fusion gene has a dual role in promoting the proliferation and inhibiting the myogenic differentiation of rhabdomyosarcoma cells. In Oncogene, 33, 5601-8. doi:10.1038/onc.2013.491. https://pubmed.ncbi.nlm.nih.gov/24213582/
6. Tanaka, Miwa, Homme, Mizuki, Teramura, Yasuyo, Maruyama, Reo, Nakamura, Takuro. 2023. HEY1-NCOA2 expression modulates chondrogenic differentiation and induces mesenchymal chondrosarcoma in mice. In JCI insight, 8, . doi:10.1172/jci.insight.160279. https://pubmed.ncbi.nlm.nih.gov/37212282/
7. Alsugair, Ziyad, Pissaloux, Daniel, Descotes, Françoise, Onea, Mihaela, Benzerdjeb, Nazim. . Uncovering the WWTR1::NCOA2 Gene fusion in low-grade myoepithelial-rich neoplasm with HMGA2 expression: A case report. In Genes, chromosomes & cancer, 63, e23244. doi:10.1002/gcc.23244. https://pubmed.ncbi.nlm.nih.gov/38747338/
8. Watson, Sarah, Perrin, Virginie, Guillemot, Delphine, Delattre, Olivier, Tirode, Franck. 2018. Transcriptomic definition of molecular subgroups of small round cell sarcomas. In The Journal of pathology, 245, 29-40. doi:10.1002/path.5053. https://pubmed.ncbi.nlm.nih.gov/29431183/
9. Nathany, Shrinidhi, Tripathi, Rupal, Mehta, Anurag. 2020. Gene of the month: GTF2I. In Journal of clinical pathology, 74, 1-4. doi:10.1136/jclinpath-2020-207013. https://pubmed.ncbi.nlm.nih.gov/32907914/