Gpcpd1-KO 基因敲除小鼠

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产品名称

Gpcpd1-KO 基因敲除小鼠

产品编号

S-KO-17811

品系全称

C57BL/6JCya-Gpcpd1em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-74182-Gpcpd1-B6J-VB

品系状态

使用本品系发表的文献需注明: Gpcpd1-KO 基因敲除小鼠 mice (Strain S-KO-17811) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
glycerophosphocholine phosphodiesterase 1
基因别称
2310004G06Rik,2310032D16Rik,Gde5,Prei4,mKIAA1434
染色体号
Chr 2 (Mouse)
转录本 ID
NCBI: NM_001355651 | Ensembl: ENSMUST00000110142
修饰方式
全身性基因敲除
靶向范围
Exon 9~10
敲除长度
~1.7 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:104898Mice with loss of expression in muscles display age-related impaired glucose tolerance, accumulation of glycerophosphocholine in muslces, and increased glucose uptake by muscles.
Gpcpd1,也称为甘油磷酸胆碱二酯酶1,是一种在多种生物过程中发挥重要作用的酶。它参与甘油磷脂代谢,甘油磷脂是细胞膜的重要组成成分,对维持细胞结构和功能至关重要。Gpcpd1通过催化甘油磷酸胆碱转化为甘油和胆碱,在甘油磷脂的合成和降解过程中发挥关键作用。

Gpcpd1在多种生物学过程中发挥重要作用。例如,在非酒精性脂肪肝疾病(NAFLD)中,Gpcpd1的表达水平受到影响,其代谢产物的水平也随之改变[1]。此外,Gpcpd1的表达水平与乳腺癌的转移和耐药性相关,抑制Gpcpd1的表达可以降低乳腺癌细胞的转移能力和耐药性[3,7]。此外,Gpcpd1的表达水平与年龄相关的肌肉萎缩症(sarcopenia)的诊断和进展相关[4]。Gpcpd1的表达水平与人类视觉皮层表面积的变异相关,这可能与视觉感知和视觉敏锐度有关[2]。最后,Gpcpd1的表达水平与鸡肉中的醛类风味化合物相关,这些化合物对鸡肉的风味有重要贡献[5,6]。

综上所述,Gpcpd1是一种重要的酶,参与甘油磷脂代谢,并在多种生物学过程中发挥重要作用。Gpcpd1的表达水平与多种疾病的发生和进展相关,包括NAFLD、乳腺癌、sarcopenia等。此外,Gpcpd1的表达水平与人类视觉皮层表面积的变异和鸡肉中的醛类风味化合物相关。Gpcpd1的研究有助于深入理解甘油磷脂代谢的生物学功能和疾病发生机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Bai, Yu, Nan, Yanyang, Wu, Tao, Fan, Jiajun, Ju, Dianwen. 2024. Lipid Nanoparticle-Mediated Delivery of CRISPR-Cas9 Against Rubicon Ameliorates NAFLD by Modulating CD36 Along with Glycerophospholipid Metabolism. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11, e2400493. doi:10.1002/advs.202400493. https://pubmed.ncbi.nlm.nih.gov/38894572/
2. Bakken, Trygve E, Roddey, J Cooper, Djurovic, Srdjan, Bosson-Heenan, Joan, Carlson, Heatherly. 2012. Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. In Proceedings of the National Academy of Sciences of the United States of America, 109, 3985-90. doi:10.1073/pnas.1105829109. https://pubmed.ncbi.nlm.nih.gov/22343285/
3. Glotzbach, Annika, Rohlf, Katharina, Gonscharow, Anastasia, Edlund, Karolina, Marchan, Rosemarie. 2024. EDI3 knockdown in ER-HER2+ breast cancer cells reduces tumor burden and improves survival in two mouse models of experimental metastasis. In Breast cancer research : BCR, 26, 87. doi:10.1186/s13058-024-01849-y. https://pubmed.ncbi.nlm.nih.gov/38816770/
4. Lin, Shangjin, Ling, Ming, Chen, Cong, Yang, Fengjian, Fan, Yongqian. 2022. Screening Potential Diagnostic Biomarkers for Age-Related Sarcopenia in the Elderly Population by WGCNA and LASSO. In BioMed research international, 2022, 7483911. doi:10.1155/2022/7483911. https://pubmed.ncbi.nlm.nih.gov/36147639/
5. Yuan, Xiaoya, Cui, Huanxian, Jin, Yuxi, Wen, Jie, Zhao, Guiping. 2022. Fatty acid metabolism-related genes are associated with flavor-presenting aldehydes in Chinese local chicken. In Frontiers in genetics, 13, 902180. doi:10.3389/fgene.2022.902180. https://pubmed.ncbi.nlm.nih.gov/36035160/
6. Shi, Lulu, Hu, Mingyue, Lai, Weining, Li, Feng, Yan, Shouqing. 2023. Detection of genomic variations and selection signatures in Wagyu using whole-genome sequencing data. In Animal genetics, 54, 808-812. doi:10.1111/age.13364. https://pubmed.ncbi.nlm.nih.gov/37792466/
7. Keller, Magdalena, Rohlf, Katharina, Glotzbach, Annika, Edlund, Karolina, Marchan, Rosemarie. 2023. Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth. In Journal of experimental & clinical cancer research : CR, 42, 25. doi:10.1186/s13046-022-02578-w. https://pubmed.ncbi.nlm.nih.gov/36670508/