Ccm2l-KO 基因敲除小鼠

1. Rosen, Jonathan N, Sogah, Vanessa M, Ye, Lillian Y, Mably, John D. 2013. ccm2-like is required for cardiovascular development as a novel component of the Heg-CCM pathway. In Developmental biology, 376, 74-85. doi:10.1016/j.ydbio.2013.01.006. https://pubmed.ncbi.nlm.nih.gov/23328253/

2. Choi, Jaesung P, Yang, Xi, He, Shuang, Xu, Cheng-Ran, Zheng, Xiangjian. 2021. CCM2L (Cerebral Cavernous Malformation 2 Like) Deletion Aggravates Cerebral Cavernous Malformation Through Map3k3-KLF Signaling Pathway. In Stroke, 52, 1428-1436. doi:10.1161/STROKEAHA.120.031523. https://pubmed.ncbi.nlm.nih.gov/33657857/

3. Zheng, Xiangjian, Xu, Chong, Smith, Annie O, Davis, George E, Kahn, Mark L. . Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth. In Developmental cell, 23, 342-55. doi:10.1016/j.devcel.2012.06.004. https://pubmed.ncbi.nlm.nih.gov/22898778/

4. Cullere, Xavier, Plovie, Eva, Bennett, Paul M, MacRae, Calum A, Mayadas, Tanya N. 2015. The cerebral cavernous malformation proteins CCM2L and CCM2 prevent the activation of the MAP kinase MEKK3. In Proceedings of the National Academy of Sciences of the United States of America, 112, 14284-9. doi:10.1073/pnas.1510495112. https://pubmed.ncbi.nlm.nih.gov/26540726/