Kdm6b-KO 基因敲除小鼠

1. Jiang, Yuhang, Li, Fengfeng, Gao, Bowen, Liu, Sanhong, Shen, Huiyong. 2021. KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma. In Theranostics, 11, 3868-3881. doi:10.7150/thno.53347. https://pubmed.ncbi.nlm.nih.gov/33664867/

2. Rots, Dmitrijs, Jakub, Taryn E, Keung, Crystal, Kramer, Jamie M, Kleefstra, Tjitske. 2023. The clinical and molecular spectrum of the KDM6B-related neurodevelopmental disorder. In American journal of human genetics, 110, 963-978. doi:10.1016/j.ajhg.2023.04.008. https://pubmed.ncbi.nlm.nih.gov/37196654/

3. Cao, Zhi, Shi, Xiaolei, Tian, Feng, Chung, Leland W K, Wang, Fubo. 2021. KDM6B is an androgen regulated gene and plays oncogenic roles by demethylating H3K27me3 at cyclin D1 promoter in prostate cancer. In Cell death & disease, 12, 2. doi:10.1038/s41419-020-03354-4. https://pubmed.ncbi.nlm.nih.gov/33414463/

4. Xun, Jing, Du, Lingfang, Gao, Ruifang, Mi, Xue, Tan, Xiaoyue. 2021. Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B. In Theranostics, 11, 6847-6859. doi:10.7150/thno.51864. https://pubmed.ncbi.nlm.nih.gov/34093857/

5. Hatano, Megumi, Akiyama, Yoshimitsu, Shimada, Shu, Ogawa, Yoshihiro, Tanaka, Shinji. 2023. Loss of KDM6B epigenetically confers resistance to lipotoxicity in nonalcoholic fatty liver disease-related HCC. In Hepatology communications, 7, . doi:10.1097/HC9.0000000000000277. https://pubmed.ncbi.nlm.nih.gov/37782459/