Kcnc4-KO 基因敲除小鼠

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产品名称

Kcnc4-KO 基因敲除小鼠

产品编号

S-KO-15677

品系全称

C57BL/6JCya-Kcnc4em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-99738-Kcnc4-B6J-VA

品系状态

使用本品系发表的文献需注明: Kcnc4-KO 基因敲除小鼠 mice (Strain S-KO-15677) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
potassium voltage gated channel, Shaw-related subfamily, member 4
基因别称
KSHIIIC,Kcr2-4,Kv3.4
染色体号
Chr 3 (Mouse)
转录本 ID
NCBI: NM_145922.3 | Ensembl: ENSMUST00000009617
修饰方式
全身性基因敲除
靶向范围
Exon 2~3
敲除长度
~3011 bp
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
Kcnc4,也称为Kv3.4,是一种电压门控钾通道蛋白,属于Shaw相关钾通道基因家族[5]。Shaw相关钾通道基因在哺乳动物中根据其序列同源性被定义为Shaker、Shab、Shaw和Shal四个亚家族。Kcnc4编码的蛋白质含有679个氨基酸,其基因在人类染色体1上定位[9]。Kv3.4通道主要在神经元中表达,参与调节神经元的兴奋性和放电模式[4]。

Kcnc4与多种疾病的发生和发展相关。研究表明,Kcnc4的突变与某些遗传性疾病有关。例如,Kcnc4的突变可能导致心律失常和肌肉功能障碍[1]。此外,Kcnc4还与癌症的发生和发展相关。例如,一项研究发现,Kcnc4在骨肉瘤组织和细胞系中高表达,并且Kcnc4的表达与患者的预后不良相关[2]。此外,Kcnc4还与心力衰竭相关。一项研究发现,Kcnc4在心力衰竭小鼠模型中表达下调,提示Kcnc4可能参与心力衰竭的发生和发展[3]。

此外,Kcnc4还与其他疾病相关。例如,一项研究发现,Kcnc4在糖尿病肾病患者中表达上调,提示Kcnc4可能参与糖尿病肾病的发生和发展[6]。此外,Kcnc4还与自闭症谱系障碍相关。一项研究发现,Kcnc4的突变与自闭症谱系障碍的发生相关[8]。最后,Kcnc4还与嗅觉上皮的神经发生和神经元存活相关。一项研究发现,Kcnc4在嗅觉上皮的神经发生和神经元存活中发挥重要作用[7]。

综上所述,Kcnc4是一种重要的电压门控钾通道蛋白,参与调节神经元的兴奋性和放电模式。Kcnc4与多种疾病的发生和发展相关,包括遗传性疾病、癌症、心力衰竭、糖尿病肾病、自闭症谱系障碍和嗅觉上皮的神经发生。深入研究Kcnc4的功能和机制,有助于理解这些疾病的发病机制,并为这些疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Monies, Dorota, Abouelhoda, Mohamed, AlSayed, Moeenaldeen, Meyer, Brian F, Alkuraya, Fowzan S. 2017. The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes. In Human genetics, 136, 921-939. doi:10.1007/s00439-017-1821-8. https://pubmed.ncbi.nlm.nih.gov/28600779/
2. Yao, Xiaoke, Wu, Lingna, Gu, Zuchao, Li, Jianhua. 2020. LINC01535 Promotes the Development of Osteosarcoma Through Modulating miR-214-3p/KCNC4 Axis. In Cancer management and research, 12, 5575-5585. doi:10.2147/CMAR.S232757. https://pubmed.ncbi.nlm.nih.gov/32753970/
3. Gou, Qiling, Zhao, Qianqian, Dong, Mengya, Liang, Lei, You, Hongjun. 2023. Diagnostic potential of energy metabolism-related genes in heart failure with preserved ejection fraction. In Frontiers in endocrinology, 14, 1296547. doi:10.3389/fendo.2023.1296547. https://pubmed.ncbi.nlm.nih.gov/38089628/
4. King, Elizabeth C, Patel, Vishal, Anand, Marie, Weisleder, Noah, Abbott, Geoffrey W. 2017. Targeted deletion of Kcne3 impairs skeletal muscle function in mice. In FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31, 2937-2947. doi:10.1096/fj.201600965RR. https://pubmed.ncbi.nlm.nih.gov/28356343/
5. Klocke, R, Roberds, S L, Tamkun, M M, Pongs, O, Jockusch, H. . Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal. In Genomics, 18, 568-74. doi:. https://pubmed.ncbi.nlm.nih.gov/7905852/
6. Yang, Tongyue, Feng, Qi, Shao, Mingwei, Qin, Guijun, Zhao, Yanyan. 2024. The role of metabolic memory in diabetic kidney disease: identification of key genes and therapeutic targets. In Frontiers in pharmacology, 15, 1379821. doi:10.3389/fphar.2024.1379821. https://pubmed.ncbi.nlm.nih.gov/39092227/
7. Sammeta, Neeraja, Hardin, Debra L, McClintock, Timothy S. 2010. Uncx regulates proliferation of neural progenitor cells and neuronal survival in the olfactory epithelium. In Molecular and cellular neurosciences, 45, 398-407. doi:10.1016/j.mcn.2010.07.013. https://pubmed.ncbi.nlm.nih.gov/20692344/
8. Ben-Mahmoud, Afif, Gupta, Vijay, Abdelaleem, Alice, Stanton, Lawrence W, Kim, Hyung-Goo. 2024. Genome Sequencing Identifies 13 Novel Candidate Risk Genes for Autism Spectrum Disorder in a Qatari Cohort. In International journal of molecular sciences, 25, . doi:10.3390/ijms252111551. https://pubmed.ncbi.nlm.nih.gov/39519104/
9. Ghanshani, S, Pak, M, McPherson, J D, Gutman, G A, Chandy, K G. . Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. In Genomics, 12, 190-6. doi:. https://pubmed.ncbi.nlm.nih.gov/1740329/