Ermn-KO 基因敲除小鼠

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产品名称

Ermn-KO 基因敲除小鼠

产品编号

S-KO-15090

品系全称

C57BL/6JCya-Ermnem1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-77767-Ermn-B6J-VA

品系状态

使用本品系发表的文献需注明: Ermn-KO 基因敲除小鼠 mice (Strain S-KO-15090) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
ermin, ERM-like protein
基因别称
A330104H05Rik,ermin,mKIAA1189
染色体号
Chr 2 (Mouse)
转录本 ID
NCBI: NM_029972.4 | Ensembl: ENSMUST00000090940
修饰方式
全身性基因敲除
靶向范围
Exon 1~3
敲除长度
~4958 bp
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:1925017Mice homozygous for a null allele exhibit impaired coordination and demyelination in aged mice with impaired oligodendrocyte differentiation.
基因Ermn,也称为Ermin,是一种与细胞骨架重构相关的基因,在髓鞘形成过程中具有重要作用。Ermn编码的蛋白质与细胞骨架蛋白相互作用,调节细胞骨架的动态变化,从而影响细胞的形态和功能。在神经系统中,Ermn的表达对髓鞘的生成和维持至关重要。

Ermn基因与多种神经系统疾病相关。在多发性硬化症(MS)中,Ermn的表达水平显著降低,这可能是导致髓鞘脱失的原因之一。Ermn表达的下调可能导致免疫细胞的功能异常,进而引发神经炎症和髓鞘脱失。此外,Ermn的表达异常还与自闭症谱系障碍(ASD)相关。研究发现,ASD患者的Ermn基因存在甲基化缺陷,这可能导致Ermn的表达异常,进而影响髓鞘的形成和神经发育。此外,Ermn基因的表达还与胶质母细胞瘤(GBM)的进展相关。Ermn基因的表达水平在GBM患者中升高,并且与患者的预后不良相关。这表明Ermn基因可能参与了GBM的发生和发展过程。

此外,Ermn基因的表达还与精神疾病相关。研究发现,精神分裂症患者的Ermn基因表达水平显著升高。这表明Ermn基因可能参与了精神分裂症的发病机制。Ermn基因的表达还与创伤后应激障碍(PTSD)相关。研究发现,PTSD患者的Ermn基因表达水平升高,并且与免疫相关基因网络相关。这表明Ermn基因可能参与了PTSD的发病机制。

综上所述,基因Ermn在髓鞘形成过程中具有重要作用,其表达异常与多种神经系统疾病和精神疾病相关。Ermn基因的研究有助于深入理解髓鞘形成和神经发育的机制,为相关疾病的治疗和预防提供新的思路和策略[1,2,3,4,5,6,7,8,9,10]。

参考文献:
1. Salek Esfahani, Behnaz, Gharesouran, Jalal, Ghafouri-Fard, Soudeh, Taheri, Mohammad, Rezazadeh, Maryam. 2019. Down-regulation of ERMN expression in relapsing remitting multiple sclerosis. In Metabolic brain disease, 34, 1261-1266. doi:10.1007/s11011-019-00429-w. https://pubmed.ncbi.nlm.nih.gov/31123898/
2. Novarino, Gaia, Fenstermaker, Ali G, Zaki, Maha S, Ideker, Trey, Gleeson, Joseph G. . Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. In Science (New York, N.Y.), 343, 506-511. doi:10.1126/science.1247363. https://pubmed.ncbi.nlm.nih.gov/24482476/
3. Homs, A, Codina-Solà, M, Rodríguez-Santiago, B, Cuscó, I, Pérez-Jurado, L A. 2016. Genetic and epigenetic methylation defects and implication of the ERMN gene in autism spectrum disorders. In Translational psychiatry, 6, e855. doi:10.1038/tp.2016.120. https://pubmed.ncbi.nlm.nih.gov/27404287/
4. Zhang, Lei, Xue, Zhenyu, Liu, Qidong, Qiu, Zilong, Jiang, Hong. 2019. Disrupted folate metabolism with anesthesia leads to myelination deficits mediated by epigenetic regulation of ERMN. In EBioMedicine, 43, 473-486. doi:10.1016/j.ebiom.2019.04.048. https://pubmed.ncbi.nlm.nih.gov/31060905/
5. Saltanova, V A, Kicherova, O A, Reikhert, L I, Doyan, Yu I, Mazurov, N A. . [Genetic basis of postoperative cognitive dysfunction]. In Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 124, 43-47. doi:10.17116/jnevro202412404143. https://pubmed.ncbi.nlm.nih.gov/38676676/
6. Yang, Yushi, Chu, Liangzhao, Zeng, Zhirui, Hu, Yaxin, Liu, Jian. . Four specific biomarkers associated with the progression of glioblastoma multiforme in older adults identified using weighted gene co-expression network analysis. In Bioengineered, 12, 6643-6654. doi:10.1080/21655979.2021.1975980. https://pubmed.ncbi.nlm.nih.gov/34516348/
7. Logue, Mark W, Zhou, Zhenwei, Morrison, Filomene G, Huber, Bertrand Russell, Miller, Mark W. 2021. Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD. In Neurobiology of stress, 15, 100398. doi:10.1016/j.ynstr.2021.100398. https://pubmed.ncbi.nlm.nih.gov/34646915/
8. Wang, Shan, Wang, Tao, Liu, Tao, Jia, Lin-Tao, Han, Jing. 2020. Ermin is a p116RIP -interacting protein promoting oligodendroglial differentiation and myelin maintenance. In Glia, 68, 2264-2276. doi:10.1002/glia.23838. https://pubmed.ncbi.nlm.nih.gov/32530539/
9. Farhang, Sara, Sabaie, Hani, Gharesouran, Jalal, Taheri, Mohammad, Rezazadeh, Maryam. 2021. Expression Analysis of Ermin and Listerin E3 Ubiquitin Protein Ligase 1 Genes in the Periphery of Patients with Schizophrenia. In Journal of molecular neuroscience : MN, 72, 246-254. doi:10.1007/s12031-021-01928-1. https://pubmed.ncbi.nlm.nih.gov/34676516/
10. Shiva, Shadi, Gharesouran, Jalal, Sabaie, Hani, Taheri, Mohammad, Rezazadeh, Maryam. 2021. Expression Analysis of Ermin and Listerin E3 Ubiquitin Protein Ligase 1 Genes in Autistic Patients. In Frontiers in molecular neuroscience, 14, 701977. doi:10.3389/fnmol.2021.701977. https://pubmed.ncbi.nlm.nih.gov/34349621/