Prelid2-KO 基因敲除小鼠

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产品名称

Prelid2-KO 基因敲除小鼠

产品编号

S-KO-15067

品系全称

C57BL/6JCya-Prelid2em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-77619-Prelid2-B6J-VA

品系状态

使用本品系发表的文献需注明: Prelid2-KO 基因敲除小鼠 mice (Strain S-KO-15067) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
PRELI domain containing 2
基因别称
1700003A01Rik,C330008K14Rik
染色体号
Chr 18 (Mouse)
转录本 ID
NCBI: NM_029942.1 | Ensembl: ENSMUST00000235606
修饰方式
全身性基因敲除
靶向范围
Exon 2~4
敲除长度
~5091 bp
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
Prelid2,全称为PRELI domain containing 2,是PRELI家族成员之一,属于保守进化基因。在胚胎发育过程中,Prelid2基因的表达和调控机制尚不清楚。有研究发现,Prelid2基因在E9.5和E10.5胚胎的中脑、脊髓、视丘、耳泡和尾部表达,而在E13.5和E15.5胚胎的前脑、后脑、心脏、肺、肝脏和肾脏中表达[1]。实时定量RT-PCR结果证实了在器官分化和形成过程中,Prelid2基因在四个主要小鼠器官(大脑、心脏、肺和肝脏)中的表达模式。此外,亚硫酸氢盐测序表明,在E12.5、E18.5和新出生小鼠中,Prelid2基因的表达与其基因组启动子区域的非甲基化状态一致。这些结果表明,Prelid2基因在胚胎发育过程中广泛表达,且持续非甲基化。

除了在胚胎发育中的作用外,Prelid2基因还与一些疾病相关。例如,在胰腺导管腺癌(PDAC)细胞中,Prelid2基因的表达与缺氧相关,并且其抑制能够更有效地抑制肿瘤细胞生长[2]。此外,在多囊卵巢综合征(PCOS)患者中,Prelid2基因的表达下调,而miR-486-5p的表达上调,这表明Prelid2基因可能参与PCOS的发生发展[3]。此外,Prelid2基因还与精神运动发育迟缓相关[4],以及与冠状动脉疾病(CAD)相关[5]。

除了上述研究外,还有研究通过RNA-Seq分析发现Prelid2基因与鼻咽癌放疗反应相关[6],以及在肾透明细胞癌(ccRCC)中构建了包含Prelid2基因的ceRNA网络[7]。此外,Prelid2基因还与猪的饲料效率相关[8],以及在大型白猪繁殖性状的GWAS研究中被确定为重要候选基因[9]。

综上所述,Prelid2基因在胚胎发育、疾病发生发展以及动物繁殖性状等方面发挥着重要作用。进一步研究Prelid2基因的功能和机制,有望为相关疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Gao, Mengya, Liu, Qi, Zhang, Fengwei, Chen, Yan, Wu, Qiong. 2009. Conserved expression of the PRELI domain containing 2 gene (Prelid2) during mid-later-gestation mouse embryogenesis. In Journal of molecular histology, 40, 227-33. doi:10.1007/s10735-009-9234-1. https://pubmed.ncbi.nlm.nih.gov/19847657/
2. Imanishi, Masaki, Inoue, Takahisa, Fukushima, Keijo, Ikeda, Yasumasa, Tsuchiya, Koichiro. 2023. CA9 and PRELID2; hypoxia-responsive potential therapeutic targets for pancreatic ductal adenocarcinoma as per bioinformatics analyses. In Journal of pharmacological sciences, 153, 232-242. doi:10.1016/j.jphs.2023.10.003. https://pubmed.ncbi.nlm.nih.gov/37973221/
3. Wang, Wei, Ji, Juan, Li, Jin, Guo, Qian, Tan, Yong. 2019. Several critical genes and microRNAs associated with the development of polycystic ovary syndrome. In Annales d'endocrinologie, 81, 18-27. doi:10.1016/j.ando.2019.10.002. https://pubmed.ncbi.nlm.nih.gov/32127169/
4. Falcone, Noemi, Ranieri, Annaluisa, Vitale, Andrea, Pastore, Lucio, Lombardo, Barbara. 2022. Identification of a De Novo Deletion by Using A-CGH Involving PLNAX2: An Interesting Candidate Gene in Psychomotor Developmental Delay. In Medicina (Kaunas, Lithuania), 58, . doi:10.3390/medicina58040524. https://pubmed.ncbi.nlm.nih.gov/35454363/
5. Nolan, Daniel K, Sutton, Beth, Haynes, Carol, Hauser, Elizabeth R, Shah, Svati H. 2012. Fine mapping of a linkage peak with integration of lipid traits identifies novel coronary artery disease genes on chromosome 5. In BMC genetics, 13, 12. doi:10.1186/1471-2156-13-12. https://pubmed.ncbi.nlm.nih.gov/22369142/
6. Liu, Guohong, Zeng, Xiaojiao, Wu, Balu, Zhao, Jin, Pan, Yunbao. 2019. RNA-Seq analysis of peripheral blood mononuclear cells reveals unique transcriptional signatures associated with radiotherapy response of nasopharyngeal carcinoma and prognosis of head and neck cancer. In Cancer biology & therapy, 21, 139-146. doi:10.1080/15384047.2019.1670521. https://pubmed.ncbi.nlm.nih.gov/31698994/
7. Lu, Wenjun, Liu, Hengchen, Zhang, Xin, Yang, Shulong, Li, Zhaozhu. 2022. A ceRNA Network Composed of Survival-Related lncRNAs, miRNAs, and mRNAs in Clear Cell Renal Carcinoma. In Computational and mathematical methods in medicine, 2022, 8504441. doi:10.1155/2022/8504441. https://pubmed.ncbi.nlm.nih.gov/35529267/
8. Fu, Lu, Jiang, Yao, Wang, Chonglong, Song, Hailiang, Ding, Xiangdong. 2020. A Genome-Wide Association Study on Feed Efficiency Related Traits in Landrace Pigs. In Frontiers in genetics, 11, 692. doi:10.3389/fgene.2020.00692. https://pubmed.ncbi.nlm.nih.gov/32719719/
9. Wang, Y, Ding, X, Tan, Z, Sun, D, Wang, C. 2018. Genome-wide association study for reproductive traits in a Large White pig population. In Animal genetics, 49, 127-131. doi:10.1111/age.12638. https://pubmed.ncbi.nlm.nih.gov/29411893/