Glt8d2-KO 基因敲除小鼠

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产品名称

Glt8d2-KO 基因敲除小鼠

产品编号

S-KO-14526

品系全称

C57BL/6JCya-Glt8d2em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-74782-Glt8d2-B6J-VA

品系状态

使用本品系发表的文献需注明: Glt8d2-KO 基因敲除小鼠 mice (Strain S-KO-14526) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
glycosyltransferase 8 domain containing 2
基因别称
1110021D20Rik
染色体号
Chr 10 (Mouse)
转录本 ID
NCBI: NM_029102.3 | Ensembl: ENSMUST00000020485
修饰方式
全身性基因敲除
靶向范围
Exon 3~5
敲除长度
~8205 bp
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:1922032Homozygous mutant mice show reduced viability and a decreased serum immunoglobulin response to antigen.
GLT8D2,也称为Glycosyltransferase 8 domain containing 2,是一种糖基转移酶家族成员,参与糖基化过程。糖基化是一种重要的蛋白质修饰方式,广泛存在于真核细胞中,对蛋白质的功能和稳定性有重要影响。GLT8D2具有糖基转移酶活性,可以催化糖基转移到蛋白质或其他分子上,从而影响其结构和功能。

GLT8D2在多种疾病中发挥重要作用,包括肺动脉高压、胃癌、膀胱尿路上皮癌和腺肌症。在肺动脉高压中,GLT8D2与不良预后相关,可能作为治疗靶点[1]。在胃癌中,GLT8D2作为预后生物标志物,与免疫细胞浸润和不良预后相关[2][3][6][8]。在膀胱尿路上皮癌中,GLT8D2与其他10个糖基转移酶基因共同构建了一个预后模型,用于预测患者的生存率[5]。在腺肌症中,GLT8D2作为诊断生物标志物,与免疫细胞浸润相关[7]。

GLT8D2在肝细胞中也发挥作用,可以正调节ApoB100蛋白的表达。ApoB100是低密度脂蛋白(VLDL)的重要组成成分,其糖基化可能影响VLDL的组装和分泌。GLT8D2可以与ApoB100相互作用,并提高其在肝细胞中的水平[4]。

GLT8D2在骨强度和骨质疏松症的发生中也发挥作用。通过系统遗传学分析,GLT8D2被确定为与骨强度相关的基因之一[9]。

综上所述,GLT8D2是一种重要的糖基转移酶,参与糖基化过程,影响蛋白质的功能和稳定性。GLT8D2在多种疾病中发挥重要作用,包括肺动脉高压、胃癌、膀胱尿路上皮癌和腺肌症。GLT8D2的研究有助于深入理解糖基化的生物学功能和疾病发生机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Bai, Zeyang, Xu, Lianyan, Dai, Yong, Yuan, Qingchen, Zhou, Zihua. . ECM2 and GLT8D2 in human pulmonary artery hypertension: fruits from weighted gene co-expression network analysis. In Journal of thoracic disease, 13, 2242-2254. doi:10.21037/jtd-20-3069. https://pubmed.ncbi.nlm.nih.gov/34012575/
2. Wang, Han, Zheng, Jiabin, Ma, Qingyang, Zhang, Junchang, Li, Yong. 2024. GLT8D2 is a prognostic biomarker and regulator of immune cell infiltration in gastric cancer. In Frontiers in immunology, 15, 1370367. doi:10.3389/fimmu.2024.1370367. https://pubmed.ncbi.nlm.nih.gov/38840920/
3. Xu, Huimei, Huang, Ke, Lin, Yimin, Ma, Xueni, Zhang, Dekui. 2023. Glycosyltransferase GLT8D1 and GLT8D2 serve as potential prognostic biomarkers correlated with Tumor Immunity in Gastric Cancer. In BMC medical genomics, 16, 123. doi:10.1186/s12920-023-01559-y. https://pubmed.ncbi.nlm.nih.gov/37277853/
4. Wei, Hong-Shan, Wei, Hong-Lian, Zhao, Fei, Zhong, Le-Ping, Zhan, Yu-Tao. 2013. Glycosyltransferase GLT8D2 positively regulates ApoB100 protein expression in hepatocytes. In International journal of molecular sciences, 14, 21435-46. doi:10.3390/ijms141121435. https://pubmed.ncbi.nlm.nih.gov/24173238/
5. Li, Weiping, Zuo, Kangwei, Zhao, Qi, Liu, Cheng, Jing, Suoshi. 2024. An 11-gene glycosyltransferases-related model for the prognosis of patients with bladder urothelial carcinoma: development and validation based on TCGA and GEO datasets. In Translational andrology and urology, 13, 2771-2786. doi:10.21037/tau-2024-632. https://pubmed.ncbi.nlm.nih.gov/39816229/
6. Gu, Lei, Ding, Dan, Wei, Cuicui, Zhou, Donglei. 2023. Cancer-associated fibroblasts refine the classifications of gastric cancer with distinct prognosis and tumor microenvironment characteristics. In Frontiers in oncology, 13, 1158863. doi:10.3389/fonc.2023.1158863. https://pubmed.ncbi.nlm.nih.gov/37404754/
7. Liu, Dan, Yin, Xiangjie, Guan, Xiaohong, Li, Kunming. 2023. Bioinformatic analysis and machine learning to identify the diagnostic biomarkers and immune infiltration in adenomyosis. In Frontiers in genetics, 13, 1082709. doi:10.3389/fgene.2022.1082709. https://pubmed.ncbi.nlm.nih.gov/36685847/
8. Zhang, Ya, Chen, Haoran, Zhang, Wenzheng, Zhou, Haiyan. 2024. Identification of cancer-associated fibroblast-related Ectodysplasin-A as a novel indicator for prognosis and immune response in gastric cancer. In Heliyon, 10, e34005. doi:10.1016/j.heliyon.2024.e34005. https://pubmed.ncbi.nlm.nih.gov/39091933/
9. Al-Barghouthi, Basel M, Mesner, Larry D, Calabrese, Gina M, Pomp, Daniel, Farber, Charles R. 2021. Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength. In Nature communications, 12, 3408. doi:10.1038/s41467-021-23649-0. https://pubmed.ncbi.nlm.nih.gov/34099702/