MGI:1921703Homozygous knock-out affects node cilia and results in abnormal placental labyrinth vasculature morphology, placental hemorrhage and necrosis, and partial preweaning lethality. Mice homozygous for a different null allele exhibit impaired survival, situs inversus, hydrocephaly, and male infertility with oligozoospermia and abnormal head and flagellum morphology.