Zdbf2-KO 基因敲除小鼠

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产品名称

Zdbf2-KO 基因敲除小鼠

产品编号

S-KO-14233

品系全称

C57BL/6JCya-Zdbf2em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-73884-Zdbf2-B6J-VA

品系状态

使用本品系发表的文献需注明: Zdbf2-KO 基因敲除小鼠 mice (Strain S-KO-14233) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
zinc finger, DBF-type containing 2
基因别称
4930431J08Rik,9330107J05Rik
染色体号
Chr 1 (Mouse)
转录本 ID
NCBI: NM_028673.1 | Ensembl: ENSMUST00000114132
修饰方式
全身性基因敲除
靶向范围
Exon 6
敲除长度
~131 bp
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:1921134Mice homozygous for a modified isoform encoding allele exhibit impaired methylation of the somatic differentially methylated region of the gene and decreased body weight and size when inherited paternally.
Zdbf2,也称为Zinc finger, DBF-type containing 2,是一种重要的基因,在哺乳动物的生长发育中发挥着关键作用。Zdbf2基因的父系表达对于新生儿的生长和食欲控制至关重要。研究发现,Zdbf2基因在小鼠中控制着新生儿的生长,并且这种控制是剂量敏感的,但不受父系来源的影响[1]。此外,Zdbf2基因的表达还与肌肉老化相关,研究发现Zdbf2基因与肌肉老化过程中的基因相互作用相关[2]。此外,Zdbf2基因的突变与一种罕见的遗传性疾病Nasopalpebral Lipoma-coloboma syndrome(NPLCS)相关[3]。在早期胚胎发生过程中,Zdbf2基因的表达受到DNA甲基化和染色质结构的调控[4][5][6][7][8]。综上所述,Zdbf2基因在哺乳动物的生长发育、肌肉老化、遗传性疾病和胚胎发生等方面发挥着重要作用。

参考文献:
1. Glaser, Juliane, Iranzo, Julian, Borensztein, Maud, Gaston-Massuet, Carles, Bourc'his, Deborah. 2022. The imprinted Zdbf2 gene finely tunes control of feeding and growth in neonates. In eLife, 11, . doi:10.7554/eLife.65641. https://pubmed.ncbi.nlm.nih.gov/35049495/
2. Tarum, Janelle, Ball, Graham, Gustafsson, Thomas, Altun, Mikael, Santos, Lívia. 2024. Artificial neural network inference analysis identified novel genes and gene interactions associated with skeletal muscle aging. In Journal of cachexia, sarcopenia and muscle, 15, 2143-2155. doi:10.1002/jcsm.13562. https://pubmed.ncbi.nlm.nih.gov/39210538/
3. Chacón-Camacho, Oscar F, Sobreira, Nara, You, Jing, Villegas-Ruiz, Vanessa, Zenteno, Juan C. 2016. Exome sequencing identifies a de novo frameshift mutation in the imprinted gene ZDBF2 in a sporadic patient with Nasopalpebral Lipoma-coloboma syndrome. In American journal of medical genetics. Part A, 170, 1934-7. doi:10.1002/ajmg.a.37683. https://pubmed.ncbi.nlm.nih.gov/27139419/
4. Greenberg, Maxim, Teissandier, Aurélie, Walter, Marius, Noordermeer, Daan, Bourc'his, Deborah. 2019. Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from naïve pluripotency. In eLife, 8, . doi:10.7554/eLife.44057. https://pubmed.ncbi.nlm.nih.gov/30990414/
5. Kobayashi, Hisato, Yamada, Kaori, Morita, Shinnosuke, Sotomaru, Yusuke, Kono, Tomohiro. 2009. Identification of the mouse paternally expressed imprinted gene Zdbf2 on chromosome 1 and its imprinted human homolog ZDBF2 on chromosome 2. In Genomics, 93, 461-72. doi:10.1016/j.ygeno.2008.12.012. https://pubmed.ncbi.nlm.nih.gov/19200453/
6. Matsumura, Naoki, Tsuruta, Takumi, Goto-Koshino, Yuko, Momozawa, Yukihide, Tomiyasu, Hirotaka. 2025. Comprehensive investigation of gene mutations in canine large cell gastrointestinal lymphoma. In Frontiers in veterinary science, 12, 1535446. doi:10.3389/fvets.2025.1535446. https://pubmed.ncbi.nlm.nih.gov/40046420/
7. Kobayashi, Hisato, Sakurai, Takayuki, Sato, Shun, Hata, Kenichiro, Kono, Tomohiro. 2012. Imprinted DNA methylation reprogramming during early mouse embryogenesis at the Gpr1-Zdbf2 locus is linked to long cis-intergenic transcription. In FEBS letters, 586, 827-33. doi:10.1016/j.febslet.2012.01.059. https://pubmed.ncbi.nlm.nih.gov/22449967/
8. Monteagudo-Sánchez, Ana, Richard Albert, Julien, Scarpa, Margherita, Noordermeer, Daan, Greenberg, Maxim V C. . The impact of the embryonic DNA methylation program on CTCF-mediated genome regulation. In Nucleic acids research, 52, 10934-10950. doi:10.1093/nar/gkae724. https://pubmed.ncbi.nlm.nih.gov/39180406/