Kynu-KO 基因敲除小鼠

1. Liang, Chen, Yu, Yue, Tang, Qinyu, Shen, Liangliang. . Discovering KYNU as a feature gene in hidradenitis suppurativa. In International journal of immunopathology and pharmacology, 37, 3946320231216317. doi:10.1177/03946320231216317. https://pubmed.ncbi.nlm.nih.gov/37997679/

2. Al-Mansoob, Maryam, Gupta, Ishita, Stefan Rusyniak, Radoslaw, Ouhtit, Allal. 2021. KYNU, a novel potential target that underpins CD44-promoted breast tumour cell invasion. In Journal of cellular and molecular medicine, 25, 2309-2314. doi:10.1111/jcmm.16296. https://pubmed.ncbi.nlm.nih.gov/33486887/

3. Wang, Min, Liu, Meng, Huang, Yingjian, Ying, Tingyi, Zheng, Yan. 2022. Differential Gene Expression and Methylation Analysis of Melanoma in TCGA Database to Further Study the Expression Pattern of KYNU in Melanoma. In Journal of personalized medicine, 12, . doi:10.3390/jpm12081209. https://pubmed.ncbi.nlm.nih.gov/35893303/

4. Zhang, Yu, Feng, Shi, Lv, Liemei, Li, Peipei, Zhou, Xiangxiang. 2025. Amino Acid Metabolism-Related Gene Kynureninase (KYNU) as a Prognostic Predictor and Regulator of Diffuse Large B-Cell Lymphoma. In Biochemical genetics, , . doi:10.1007/s10528-025-11047-w. https://pubmed.ncbi.nlm.nih.gov/39932613/

5. Shen, Kaiyu, Chen, Binyu, Yang, Liu, Gao, Wencang. 2023. KYNU as a Biomarker of Tumor-Associated Macrophages and Correlates with Immunosuppressive Microenvironment and Poor Prognosis in Gastric Cancer. In International journal of genomics, 2023, 4662480. doi:10.1155/2023/4662480. https://pubmed.ncbi.nlm.nih.gov/37954130/

6. Zhang, Yi, Shen, Jie, He, Xin, Jeunemaitre, Xavier, Zhu, Dingliang. 2011. A rare variant at the KYNU gene is associated with kynureninase activity and essential hypertension in the Han Chinese population. In Circulation. Cardiovascular genetics, 4, 687-94. doi:10.1161/CIRCGENETICS.110.959064. https://pubmed.ncbi.nlm.nih.gov/22012986/

7. Lu, Yu, Zhao, Xianyang, Yuan, Mingliang, Xie, Jun, Cheng, Zhongbin. 2024. KYNU Expression Promotes Cisplatin Resistance in Esophageal Cancer. In Journal of Cancer, 15, 2475-2485. doi:10.7150/jca.93229. https://pubmed.ncbi.nlm.nih.gov/38577600/

8. Zhou, Hongqing, Wang, Wei, Liu, Mingsheng, Peng, Jiaxi, Xu, Chenxiang. 2022. IDO promotes the proliferation and invasion of prostate cancer cells through KYNU. In Genes & genomics, 45, 367-376. doi:10.1007/s13258-022-01316-y. https://pubmed.ncbi.nlm.nih.gov/36264416/

9. Kretzschmar, Gabriela Canalli, Targa, Adriano D S, Soares-Lima, Sheila Coelho, Lima, Marcelo M S, Boldt, Angelica Beate Winter. 2022. Folic Acid and Vitamin B12 Prevent Deleterious Effects of Rotenone on Object Novelty Recognition Memory and Kynu Expression in an Animal Model of Parkinson's Disease. In Genes, 13, . doi:10.3390/genes13122397. https://pubmed.ncbi.nlm.nih.gov/36553663/

10. Szot, Justin O, Cuny, Hartmut, Martin, Ella Mma, Bozon, Kayleigh, Dunwoodie, Sally L. 2024. A metabolic signature for NADSYN1-dependent congenital NAD deficiency disorder. In The Journal of clinical investigation, 134, . doi:10.1172/JCI174824. https://pubmed.ncbi.nlm.nih.gov/38357931/