Cd209b-KO 基因敲除小鼠

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产品名称

Cd209b-KO 基因敲除小鼠

产品编号

S-KO-12974

品系全称

C57BL/6NCya-Cd209bem1/Cya

品系背景

C57BL/6NCya

品系编号

KOCMP-69165-Cd209b-B6N-VA

品系状态

使用本品系发表的文献需注明: Cd209b-KO 基因敲除小鼠 mice (Strain S-KO-12974) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
CD209b antigen
基因别称
1810030I22Rik,DC-SIGNR1,OtB7,SIGNR1,mSIGNR1
染色体号
Chr 8 (Mouse)
转录本 ID
NCBI: NM_026972 | Ensembl: ENSMUST00000084086
修饰方式
全身性基因敲除
靶向范围
Exon 3~8
敲除长度
~4.7 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:1916415Homozygous mutants are more susceptible to S. pneumoniae infection and fail to clear the bacteria from the circulation. Marginal zone and peritoneal macrophages are impaired in recognizing the bacteria.

发表文献

Nature Nanotechnology
2020-03-20
Dual-targeting Nanoparticle Vaccine Elicits a Therapeutic Antibody Response Against Chronic Hepatitis B
1
CD209b,也称为SIGNR1,是一种C型凝集素受体,主要在巨噬细胞和树突状细胞上表达。它属于DC-SIGN家族,能够识别并结合多种病原体,包括细菌、病毒和寄生虫。CD209b在免疫系统中发挥着重要的作用,参与调节炎症反应、抗原呈递和免疫应答[2]。

CD209b的表达与多种疾病的发生和发展密切相关。在动脉粥样硬化中,CD209b的表达水平与斑块的稳定性有关。CD209b高表达的巨噬细胞倾向于向M2型极化,促进斑块的形成和发展[1]。在肺癌症中,CD209b在肿瘤相关巨噬细胞中表达上调,并与肿瘤的免疫逃逸和转移相关[2]。此外,CD209b还与肝纤维化、疟疾和肠道感染等疾病的发生有关[3,4,5,6,7]。

CD209b在肝脏中也发挥着重要作用。研究表明,CD209b的表达水平与肝脏的炎症和纤维化程度相关。在肝脏疾病中,如泡型棘球蚴病和肝纤维化,CD209b的表达水平降低,导致肝脏功能的损害[5,6]。此外,CD209b还参与调节肝脏窦状内皮细胞的毛细血管化过程,影响肝脏的微循环和功能[5,6]。

综上所述,CD209b是一种重要的免疫调节因子,在多种疾病中发挥重要作用。CD209b的表达水平与炎症反应、肿瘤免疫逃逸、肝纤维化等疾病的发生和发展密切相关。深入研究CD209b的生物学功能和机制,有助于开发新的治疗策略,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Bosmans, Laura A, van Tiel, Claudia M, Aarts, Suzanne A B M, Shami, Annelie, Lutgens, Esther. . Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages' transition into a pro-inflammatory state. In Cardiovascular research, 119, 1146-1160. doi:10.1093/cvr/cvac084. https://pubmed.ncbi.nlm.nih.gov/35587037/
2. Yan, Xiaolong, Li, Wenhai, Pan, Lei, Chen, Min, Mu, Deguang. 2015. Lewis Lung Cancer Cells Promote SIGNR1(CD209b)-Mediated Macrophages Polarization Induced by IL-4 to Facilitate Immune Evasion. In Journal of cellular biochemistry, 117, 1158-66. doi:10.1002/jcb.25399. https://pubmed.ncbi.nlm.nih.gov/26447454/
3. de Bruijn, Irene, Belmonte, Rodrigo, Anderson, Vicky L, van West, Pieter, Secombes, Christopher J. 2012. Immune gene expression in trout cell lines infected with the fish pathogenic oomycete Saprolegnia parasitica. In Developmental and comparative immunology, 38, 44-54. doi:10.1016/j.dci.2012.03.018. https://pubmed.ncbi.nlm.nih.gov/22522286/
4. Mao, Ji-Hua, Chen, Wen-Mei, Wang, Yang, Liu, Jun, Tu, Zong-Cai. 2024. Serum metabolism-transcriptomics investigated into the immunity of whey protein isolate-galacto-oligosaccharide conjugates after dynamic high-pressure microfluidics pretreatment. In Food research international (Ottawa, Ont.), 196, 115121. doi:10.1016/j.foodres.2024.115121. https://pubmed.ncbi.nlm.nih.gov/39614521/
5. Zhang, R, Xie, J, Wei, F, Zhang, T, Chen, M. . [Dynamic observation on capillarization of liver sinusoidal endothelial cells induced by Echinococcus multilocularis infection]. In Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control, 36, 34-43. doi:10.16250/j.32.1374.2023243. https://pubmed.ncbi.nlm.nih.gov/38604683/
6. Wu, Bi-Cong, Olivia, Njiri A, Tembo, John Mambwe, Ding, Hong-Hui, Chen, Tie. 2021. Loss of the virulence plasmid by Shigella sonnei promotes its interactions with CD207 and CD209 receptors. In Journal of medical microbiology, 70, . doi:10.1099/jmm.0.001297. https://pubmed.ncbi.nlm.nih.gov/33591245/
7. Dkhil, Mohamed A, Lubbad, Mahmoud Y, Al-Shaebi, Esam M, Delic, Denis, Al-Quraishy, Saleh. 2015. The antiplasmodial and spleen protective role of crude Indigofera oblongifolia leaf extract traditionally used in the treatment of malaria in Saudi Arabia. In Drug design, development and therapy, 9, 6235-46. doi:10.2147/DDDT.S94673. https://pubmed.ncbi.nlm.nih.gov/26648699/

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