Nufip2-KO 基因敲除小鼠

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产品名称

Nufip2-KO 基因敲除小鼠

产品编号

S-KO-12758

品系全称

C57BL/6JCya-Nufip2em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-68564-Nufip2-B6J-VA

品系状态

使用本品系发表的文献需注明: Nufip2-KO 基因敲除小鼠 mice (Strain S-KO-12758) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
nuclear FMR1 interacting protein 2
基因别称
1110001M19Rik,9530056D24Rik,PIG1,mKIAA1321
染色体号
Chr 11 (Mouse)
转录本 ID
NCBI: NM_001024205 | Ensembl: ENSMUST00000100802
修饰方式
全身性基因敲除
靶向范围
Exon 2~4
敲除长度
~18.7 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
Nufip2,全称Nuclear Fragile X Mental Retardation Protein Interacting Protein 2,是一种在真核生物中广泛表达的核内蛋白。该基因编码的蛋白质在细胞内起着多种功能,包括RNA结合、mRNA运输和mRNA翻译等,参与调控基因表达和生物学过程。

Nufip2蛋白与其他核蛋白相互作用,形成复合物,参与细胞内多种重要的生物学过程。例如,Nufip2与FMRP(Fragile X Mental Retardation Protein)相互作用,参与调控RNA代谢和细胞应激反应[3]。此外,Nufip2还与Roquin蛋白相互作用,促进Roquin蛋白对mRNA的降解,从而影响免疫细胞功能和哺乳动物后天的生存[2]。

在神经退行性疾病中,Nufip2也发挥着重要作用。研究表明,Nufip2与ALS(Amyotrophic Lateral Sclerosis,肌萎缩侧索硬化症)的发生发展密切相关。在ALS患者中,Nufip2蛋白的表达水平升高,并且Nufip2是hsa-miR-335-5p等多种miRNA的靶基因[1]。此外,Nufip2还参与了DHT(Dihydrotestosterone)抑制REDOX损伤和神经炎症的过程,从而减轻PND(Perioperative Neurocognitive Disorder,围手术期神经认知障碍)的发生[4]。

在眼病研究中,Nufip2也与晶状体发育和视网膜脱离相关。研究发现,在HiSER(Hirosaki small-eye rat)突变鼠中,Nufip2基因的表达水平降低,导致晶状体发育异常和视网膜脱离[5]。此外,Nufip2还参与了肾脏结石形成的过程,通过影响上皮细胞和巨噬细胞之间的相互作用,调节肾脏结石的形成[6]。

此外,Nufip2还与多种疾病的发生发展相关。例如,NufIP2与UTUC(Upper Tract Urothelial Carcinoma,上尿路上皮癌)的发生发展密切相关,Nufip2蛋白的表达水平升高,并且Nufip2是miRNA的靶基因[7]。此外,Nufip2还参与了RA(Rheumatoid Arthritis,类风湿性关节炎)的发生发展,Nufip2蛋白的表达水平升高,并且Nufip2是miRNA的靶基因[8]。此外,Nufip2还与发育迟缓和发育畸形相关,Nufip2基因的缺失或突变可能导致发育迟缓和发育畸形[9]。

综上所述,Nufip2是一种重要的核内蛋白,参与调控RNA代谢、细胞应激反应、神经退行性疾病、眼病、肾脏结石形成、UTUC、RA和发育异常等多种生物学过程。Nufip2的研究有助于深入理解细胞内RNA代谢和基因表达的调控机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Hamzeiy, Hamid, Suluyayla, Rabia, Brinkrolf, Christoph, Hofestädt, Ralf, Allmer, Jens. . Visualization and Analysis of miRNAs Implicated in Amyotrophic Lateral Sclerosis Within Gene Regulatory Pathways. In Studies in health technology and informatics, 253, 183-187. doi:. https://pubmed.ncbi.nlm.nih.gov/30147069/
2. Rehage, Nina, Davydova, Elena, Conrad, Christine, Niessing, Dierk, Heissmeyer, Vigo. 2018. Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA. In Nature communications, 9, 299. doi:10.1038/s41467-017-02582-1. https://pubmed.ncbi.nlm.nih.gov/29352114/
3. Taha, Mohamed S, Haghighi, Fereshteh, Stefanski, Anja, Stühler, Kai, Ahmadian, Mohammad R. 2020. Novel FMRP interaction networks linked to cellular stress. In The FEBS journal, 288, 837-860. doi:10.1111/febs.15443. https://pubmed.ncbi.nlm.nih.gov/32525608/
4. Liu, Li, Liu, Mei, Zhang, Daying, Song, Zhiping, Zhang, Huaigen. 2023. DHT inhibits REDOX damage and neuroinflammation to reduce PND occurrence in aged mice via mmu_circ_0001442/miR-125a-3p/NUFIP2 axis. In Brain and behavior, 13, e3180. doi:10.1002/brb3.3180. https://pubmed.ncbi.nlm.nih.gov/37550899/
5. Yamada, Toshiyuki, Nanashima, Naoki, Shimizu, Takeshi, Nakazawa, Mitsuru, Tsuchida, Shigeki. 2015. Establishment of a recessive mutant small-eye rat with lens involution and retinal detachment associated with partial deletion and rearrangement of the Cryba1 gene. In The Biochemical journal, 471, 293-305. doi:10.1042/BJ20150165. https://pubmed.ncbi.nlm.nih.gov/26303524/
6. Sun, Yushi, Li, Bojun, Zhou, Xiangjun, Rao, Ting, Cheng, Fan. 2024. The identification of key molecules and pathways in the crosstalk of calcium oxalate-treated TCMK-1 cells and macrophage via exosomes. In Scientific reports, 14, 20949. doi:10.1038/s41598-024-71755-y. https://pubmed.ncbi.nlm.nih.gov/39251681/
7. Fu, Tingting, Lin, Yifei, Lin, Ling, Liao, Banghua, Huang, Jin. 2022. Network architecture of non-coding RNAs provides insights into the pathogenesis of upper tract urothelial carcinoma. In Urologic oncology, 40, 383.e11-383.e21. doi:10.1016/j.urolonc.2022.05.003. https://pubmed.ncbi.nlm.nih.gov/35659483/
8. Wu, Cuiyan, Tan, Sijian, Liu, Li, Wen, Yan, Zhang, Feng. 2021. Transcriptome-wide association study identifies susceptibility genes for rheumatoid arthritis. In Arthritis research & therapy, 23, 38. doi:10.1186/s13075-021-02419-9. https://pubmed.ncbi.nlm.nih.gov/33482886/
9. Xie, Bobo, Fan, Xin, Lei, Yaqin, Chen, Shaoke, Shen, Yiping. 2016. A novel de novo microdeletion at 17q11.2 adjacent to NF1 gene associated with developmental delay, short stature, microcephaly and dysmorphic features. In Molecular cytogenetics, 9, 41. doi:10.1186/s13039-016-0251-y. https://pubmed.ncbi.nlm.nih.gov/27247625/