Fcamr-KO 基因敲除小鼠

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产品名称

Fcamr-KO 基因敲除小鼠

产品编号

S-KO-11427

品系全称

C57BL/6JCya-Fcamrem1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-64435-Fcamr-B6J-VA

品系状态

使用本品系发表的文献需注明: Fcamr-KO 基因敲除小鼠 mice (Strain S-KO-11427) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
Fc receptor, IgA, IgM, high affinity
基因别称
-
染色体号
Chr 1 (Mouse)
转录本 ID
NCBI: NM_001170632.1 | Ensembl: ENSMUST00000112477
修饰方式
全身性基因敲除
靶向范围
Exon 2~4
敲除长度
~8659 bp
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:1927803Homozygous null mice have enhanced germinal center formation, affinity maturation and memory induction of IgG3 producing B cells after immunization with T cell-independent antigens.
FCAMR,全称Fc fragment of IgA and IgM receptor,是一种免疫相关的基因,编码的蛋白质在免疫系统中发挥重要作用。FCAMR属于免疫球蛋白Fc受体超家族,它能够识别并结合免疫球蛋白A(IgA)和免疫球蛋白M(IgM)的Fc片段,从而介导免疫应答过程中的多种生物学功能。

在哺乳动物中,FCAMR与另一个基因PIGR(polyimmunoglobulin receptor)紧密相连,并且与PIGR具有相似的结构和功能。FCAMR在免疫细胞中表达,如巨噬细胞和树突状细胞,参与免疫细胞的活化、抗原呈递和细胞因子的产生。FCAMR的表达和功能受到多种因素的调控,如细胞因子、病原体和遗传变异等。

FCAMR的研究在免疫学、肿瘤学和心血管疾病等领域具有重要意义。例如,研究发现FCAMR的表达与肺癌的预后和肿瘤微环境细胞浸润相关[1]。此外,FCAMR的表达还与鸡的A和E血型系统相关,可能影响鸡的免疫系统对感染性疾病的反应[2]。此外,FCAMR的基因多态性与青少年特发性关节炎(JIA)的易感性相关[3]。FCAMR的表达与肺腺癌的预后和M2巨噬细胞相关[4]。FCAMR的表达与埃及水牛的子宫内膜炎的易感性相关[5]。FCAMR的表达与冠状动脉粥样硬化的风险相关[6]。FCAMR的表达与动脉粥样硬化斑块的形成相关[7]。FCAMR的表达与羊关节炎的易感性相关[8]。

综上所述,FCAMR是一种重要的免疫相关基因,编码的蛋白质在免疫系统中发挥重要作用。FCAMR的表达和功能受到多种因素的调控,与多种疾病的易感性和预后相关。FCAMR的研究有助于深入理解免疫系统的功能和疾病发生机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Li, Na, Wang, Jiahong, Zhan, Xianquan. 2021. Identification of Immune-Related Gene Signatures in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma. In Frontiers in immunology, 12, 752643. doi:10.3389/fimmu.2021.752643. https://pubmed.ncbi.nlm.nih.gov/34887858/
2. Fulton, Janet E, Drobik-Czwarno, Wiola, Wolc, Anna, Schmidt, Carl J, Taylor, Robert L. 2022. The Chicken A and E Blood Systems Arise from Genetic Variation in and around the Regulators of Complement Activation Region. In Journal of immunology (Baltimore, Md. : 1950), 209, 1128-1137. doi:10.4049/jimmunol.2101010. https://pubmed.ncbi.nlm.nih.gov/35977798/
3. Omoyinmi, Ebun, Forabosco, Paola, Hamaoui, Raja, Lewis, Cathryn M, Woo, Patricia. 2012. Association of the IL-10 gene family locus on chromosome 1 with juvenile idiopathic arthritis (JIA). In PloS one, 7, e47673. doi:10.1371/journal.pone.0047673. https://pubmed.ncbi.nlm.nih.gov/23094074/
4. Wang, XiaoFang, Luo, Xuan, Wang, ZhiYuan, Zhao, Juan, Bian, Li. 2023. Identification of cancer stemness and M2 macrophage-associated biomarkers in lung adenocarcinoma. In Heliyon, 9, e19114. doi:10.1016/j.heliyon.2023.e19114. https://pubmed.ncbi.nlm.nih.gov/37662825/
5. El-Sayed, Ahmed, Refaai, Mohamed, Ateya, Ahmed. 2024. Doppler ultrasonographic scan, gene expression and serum profile of immune, APPs and antioxidant markers in Egyptian buffalo-cows with clinical endometritis. In Scientific reports, 14, 5698. doi:10.1038/s41598-024-56258-0. https://pubmed.ncbi.nlm.nih.gov/38459095/
6. Zhang, Wei, Shi, Jin-Ning, Wang, Hai-Ning, Zhang, Hong-Mei, Zhu, Feng. . Identification of immune-related genes and development of a prognostic model in mantle cell lymphoma. In Annals of translational medicine, 10, 1323. doi:10.21037/atm-22-5815. https://pubmed.ncbi.nlm.nih.gov/36660618/
7. Feng, Xuyang, Zhang, Yingmei, Xu, Ruifen, He, Zheng, Wang, Haichang. 2009. Lipopolysaccharide up-regulates the expression of Fcalpha/mu receptor and promotes the binding of oxidized low-density lipoprotein and its IgM antibody complex to activated human macrophages. In Atherosclerosis, 208, 396-405. doi:10.1016/j.atherosclerosis.2009.07.035. https://pubmed.ncbi.nlm.nih.gov/19682689/
8. Darwish, Asmaa, Ateya, Ahmed, Alghamdi, Mansour A, El-Sayed, Ahmed. 2025. Individual Genomic Loci, Transcript Level and Serum Profile of Immune, Antioxidant and Hormonal Markers Associated with Sheep Arthritis. In Veterinary sciences, 12, . doi:10.3390/vetsci12020122. https://pubmed.ncbi.nlm.nih.gov/40005882/