智鼠故事 
Fgf21-KO 基因敲除小鼠
复苏/繁育服务
产品名称
Fgf21-KO 基因敲除小鼠
产品编号
S-KO-10895
品系全称
C57BL/6NCya-Fgf21em1/Cya
品系背景
C57BL/6NCya
品系编号
KOCMP-56636-Fgf21-B6N-VA
品系状态
使用本品系发表的文献需注明： Fgf21-KO 基因敲除小鼠 mice (Strain S-KO-10895) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因别称
Fgf8c
NCBI ID
染色体号
Chr 7
NCBI RefSeq
NM_020013
Ensembl ID
ENSMUST00000033099
修饰方式
全身性基因敲除
靶向范围
Exon 1~3
敲除长度
~1.6 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:1861377Mice homozygous for a null allele exhibit decreased circulating glucose levels, oxygen consumption, and gluconeogenesis in fasted mice and increased circulating ketone levels in fed mice.
发表文献
Nature Communications
2024-10-03
FGF21 modulates immunometabolic homeostasis via the ALOX15/15-HETE axis in early liver graft injury
DIABETOLOGIA
2022-11-04
Pancreatic alpha cell glucagon–liver FGF21 axis regulates beta cell regeneration in a mouse model of type 2 diabetes
Nutrition & Diabetes
2022-09-27
Suppression of obesity by melatonin through increasing energy expenditure and accelerating lipolysis in mice fed a high-fat diet
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