Spag5-KO 基因敲除小鼠

1. Mohamadalizadeh-Hanjani, Zeinab, Shahbazi, Shirin, Geranpayeh, Loabat. 2020. Investigation of the SPAG5 gene expression and amplification related to the NuMA mRNA levels in breast ductal carcinoma. In World journal of surgical oncology, 18, 225. doi:10.1186/s12957-020-02001-8. https://pubmed.ncbi.nlm.nih.gov/32838814/

2. Zhu, Chenjing, Menyhart, Otilia, Győrffy, Balázs, He, Xia. 2019. The prognostic association of SPAG5 gene expression in breast cancer patients with systematic therapy. In BMC cancer, 19, 1046. doi:10.1186/s12885-019-6260-6. https://pubmed.ncbi.nlm.nih.gov/31690268/

3. He, Ji, Green, Andrew R, Li, Yan, Chan, Stephen Y T, Liu, Dong-Xu. 2020. SPAG5: An Emerging Oncogene. In Trends in cancer, 6, 543-547. doi:10.1016/j.trecan.2020.03.006. https://pubmed.ncbi.nlm.nih.gov/32291236/

4. Chen, Wei, Chen, Xing, Li, Sijin, Ren, Biqiong. 2020. Expression, immune infiltration and clinical significance of SPAG5 in hepatocellular carcinoma: A gene expression-based study. In The journal of gene medicine, 22, e3155. doi:10.1002/jgm.3155. https://pubmed.ncbi.nlm.nih.gov/31860771/

5. An, Juan, Yang, Lang, Pan, Yuanming, Su, Zhanhai, Sheng, Jianqiu. . SPAG5 Activates PI3K/AKT Pathway and Promotes the Tumor Progression and Chemo-Resistance in Gastric Cancer. In DNA and cell biology, 41, 893-902. doi:10.1089/dna.2021.0531. https://pubmed.ncbi.nlm.nih.gov/36264549/

6. Li, Bo, Severson, Eric, Pignon, Jean-Christophe, Liu, Jun S, Liu, X Shirley. 2016. Comprehensive analyses of tumor immunity: implications for cancer immunotherapy. In Genome biology, 17, 174. doi:10.1186/s13059-016-1028-7. https://pubmed.ncbi.nlm.nih.gov/27549193/

7. Li, Zhiyun, Li, Hu, Chen, Jiangwei, Yao, Yao, Duan, Mansheng. 2020. SPAG5 promotes osteosarcoma metastasis via activation of FOXM1/MMP2 axis. In The international journal of biochemistry & cell biology, 126, 105797. doi:10.1016/j.biocel.2020.105797. https://pubmed.ncbi.nlm.nih.gov/32668328/

8. Zhang, Xuelian, Wu, Weiyu, Li, Xiaohui, He, Feng, Zhang, Lei. . SPAG5 promotes the proliferation, migration, invasion, and epithelial-mesenchymal transformation of colorectal cancer cells by activating the PI3K/AKT signaling pathway. In The Chinese journal of physiology, 66, 365-371. doi:10.4103/cjop.CJOP-D-22-00165. https://pubmed.ncbi.nlm.nih.gov/37929348/

9. Zeng, Xinyi, Xu, Wenbin, Tong, Jianjing, Wu, Yingli, Yan, Hua. 2022. SPAG5 as a novel biomarker and potential therapeutic target via regulating AKT pathway in multiple myeloma. In Leukemia & lymphoma, 63, 2565-2572. doi:10.1080/10428194.2022.2086247. https://pubmed.ncbi.nlm.nih.gov/35730922/