智鼠故事 
C57BL/6NCya-Prknem1/Cya 全身性基因敲除小鼠
复苏/繁育服务
产品名称
Prkn-KO
产品编号
S-KO-10233
品系全称
C57BL/6NCya-Prknem1/Cya
品系背景
C57BL/6NCya
品系编号
KOCMP-50873-Prkn-B6N-VA
品系状态
使用本品系发表的文献需注明： Prkn-KO mice (Strain S-KO-10233) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因别称
Park2
NCBI ID
染色体号
Chr 17
NCBI RefSeq
NM_016694
Ensembl ID
ENSMUST00000191124
修饰方式
全身性基因敲除
靶向范围
Exon 4
敲除长度
~1.3 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:1355296Dopamine and glutatamate transmission are impaired in some targeted null mice, resulting in decreased exploratory behavior. These mice show decreased body weight and temperature. Park2 is inactivated as part of a large deletion in the quaking mouse, a dysmyelinating mutant with a pronounced tremor.
发表文献
Ecotoxicology and Environmental Safety
2023-10-01
Parkin-mediated mitophagy protects against aluminum trichloride-induced hippocampal apoptosis in mice via the mtROS-NLRP3 pathway
Food and Chemical Toxicology
2023-06-01
Mitophagy alleviates AIF-mediated spleen apoptosis induced by AlCl3 through Parkin stabilization in mice
Journal of Translational Medicine
2020-03-20
Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury.
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