Fndc5-KO 基因敲除小鼠

1. Wrann, Christiane D, White, James P, Salogiannnis, John, Greenberg, Michael E, Spiegelman, Bruce M. 2013. Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. In Cell metabolism, 18, 649-59. doi:10.1016/j.cmet.2013.09.008. https://pubmed.ncbi.nlm.nih.gov/24120943/

2. Guo, Mingwei, Yao, Jing, Li, Jin, Xiao, Junjie, Ma, Xinran. 2022. Irisin ameliorates age-associated sarcopenia and metabolic dysfunction. In Journal of cachexia, sarcopenia and muscle, 14, 391-405. doi:10.1002/jcsm.13141. https://pubmed.ncbi.nlm.nih.gov/36510115/

3. Yang, Xianqin, Ni, Li, Sun, Junyu, Yuan, Xiaolu, Li, Dezhong. 2022. Associations between rs3480 and rs16835198 gene polymorphisms of FNDC5 with type 2 diabetes mellitus susceptibility: a meta-analysis. In Frontiers in endocrinology, 13, 946982. doi:10.3389/fendo.2022.946982. https://pubmed.ncbi.nlm.nih.gov/36004352/

4. Boström, Pontus, Wu, Jun, Jedrychowski, Mark P, Gygi, Steven P, Spiegelman, Bruce M. 2012. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. In Nature, 481, 463-8. doi:10.1038/nature10777. https://pubmed.ncbi.nlm.nih.gov/22237023/

5. Perrone, Benedetta, Ruffo, Paola, Zelasco, Samanta, Bonofiglio, Daniela, Conforti, Francesca Luisa. 2022. LPL, FNDC5 and PPARγ gene polymorphisms related to body composition parameters and lipid metabolic profile in adolescents from Southern Italy. In Journal of translational medicine, 20, 107. doi:10.1186/s12967-022-03314-w. https://pubmed.ncbi.nlm.nih.gov/35241092/

6. Islam, Mohammad R, Valaris, Sophia, Young, Michael F, Spiegelman, Bruce M, Wrann, Christiane D. 2021. Exercise hormone irisin is a critical regulator of cognitive function. In Nature metabolism, 3, 1058-1070. doi:10.1038/s42255-021-00438-z. https://pubmed.ncbi.nlm.nih.gov/34417591/