Npsr1-KO 基因敲除小鼠

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产品名称

Npsr1-KO 基因敲除小鼠

产品编号

S-KO-09129

品系全称

C57BL/6JCya-Npsr1em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-319239-Npsr1-B6J-VA

品系状态

使用本品系发表的文献需注明: Npsr1-KO 基因敲除小鼠 mice (Strain S-KO-09129) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
neuropeptide S receptor 1
基因别称
9330128H10Rik,GPRA,Gpr154,MVTR,PGR14,VRR1
染色体号
Chr 9 (Mouse)
转录本 ID
NCBI: NM_175678 | Ensembl: ENSMUST00000059650
修饰方式
全身性基因敲除
靶向范围
Exon 3
敲除长度
~0.1 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:2441738Mice homozygous for a knock-out allele exhibit decreased airway resistance when treated with high concentrations of U-46619. Heterozygosity for p.Y206H mutation leads to shorter sleep periods without sleep deprivation-related memory phenotypes.
Npsr1,也称为Neuropeptide S receptor 1,是一种重要的G蛋白偶联受体。它编码两种不同的受体变体,NPSR1-A和NPSR1-B,这两种变体在哮喘、过敏和焦虑等疾病的发生发展中具有重要作用。NPSR1-A和NPSR1-B的信号传导特性存在差异,这可能与哮喘和过敏的病理过程有关[3]。

研究表明,NPSR1基因的某些多态性与失眠、焦虑、哮喘、关节炎和慢性腹痛等疾病的发生发展有关。例如,rs324957和rs324981多态性与原发性失眠的发生风险增加有关[1]。NPSR1基因变异与焦虑障碍的发生风险相关,如广泛性焦虑障碍(GAD)[2]。NPSR1基因变异与哮喘和过敏的易感性相关[3]。NPSR1基因变异与类风湿性关节炎的发生风险降低相关[5]。NPSR1基因变异与儿童反复性腹痛的发生风险增加相关[9]。

NPSR1基因变异还与神经系统的功能相关。例如,NPSR1基因的A/T多态性(rs324981)与恐惧处理的神经相关有关[4]。NPSR1基因变异与恐慌症和广场恐惧症的神经活动相关[8]。

此外,NPSR1基因变异还与慢性应激反应相关。例如,NPSR1基因变异与皮质醇觉醒反应(CAR)的变化相关,这种关联在慢性应激暴露下更为明显[6]。

NPSR1基因变异还与肺癌的发生发展和预后相关。研究表明,NPSR1基因的表达水平与肺癌的不良预后相关[7]。

综上所述,NPSR1基因变异与多种疾病的发生发展和预后相关,包括失眠、焦虑、哮喘、关节炎、慢性腹痛和肺癌等。NPSR1基因变异还与神经系统的功能相关,影响恐惧处理和焦虑障碍的神经活动。此外,NPSR1基因变异还与慢性应激反应相关,影响皮质醇觉醒反应的变化。因此,NPSR1基因变异可能是多种疾病的重要遗传因素,其研究有助于深入理解疾病的发生机制和病理过程,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Xie, Yuping, Zhao, Yuan, Zhou, Liya, Chen, Wenjuan, Wang, Jing. . Gene polymorphisms (rs324957, rs324981) in NPSR1 are associated with increased risk of primary insomnia: A cross-sectional study. In Medicine, 99, e21598. doi:10.1097/MD.0000000000021598. https://pubmed.ncbi.nlm.nih.gov/32846769/
2. Gottschalk, Michael G, Domschke, Katharina. . Genetics of generalized anxiety disorder and related traits. In Dialogues in clinical neuroscience, 19, 159-168. doi:. https://pubmed.ncbi.nlm.nih.gov/28867940/
3. Pietras, Christina Orsmark, Vendelin, Johanna, Anedda, Francesca, Söderhäll, Cilla, Kere, Juha. 2011. The asthma candidate gene NPSR1 mediates isoform specific downstream signalling. In BMC pulmonary medicine, 11, 39. doi:10.1186/1471-2466-11-39. https://pubmed.ncbi.nlm.nih.gov/21707994/
4. Leehr, Elisabeth J, Brede, Leonie S, Böhnlein, Joscha, Lueken, Ulrike, Dannlowski, Udo. . Impact of NPSR1 gene variation on the neural correlates of phasic and sustained fear in spider phobia-an imaging genetics and independent replication approach. In Social cognitive and affective neuroscience, 19, . doi:10.1093/scan/nsae054. https://pubmed.ncbi.nlm.nih.gov/39167471/
5. Robledo, Gema, González-Gay, Miguel Angel, Fernández-Gutiérrez, Benjamín, Delgado, Mario, Martín, Javier. 2012. NPSR1 gene is associated with reduced risk of rheumatoid arthritis. In The Journal of rheumatology, 39, 1166-70. doi:10.3899/jrheum.111205. https://pubmed.ncbi.nlm.nih.gov/22548958/
6. Peter, Hannah L, Giglberger, Marina, Frank, Josef, Kudielka, Brigitte M, Wüst, Stefan. 2022. The association between genetic variability in the NPS/NPSR1 system and chronic stress responses: A gene-environment-(quasi-) experiment. In Psychoneuroendocrinology, 144, 105883. doi:10.1016/j.psyneuen.2022.105883. https://pubmed.ncbi.nlm.nih.gov/35914393/
7. Zheng, Qiangqiang, Min, Shihui, Zhou, Qinghua. . Identification of potential diagnostic and prognostic biomarkers for LUAD based on TCGA and GEO databases. In Bioscience reports, 41, . doi:10.1042/BSR20204370. https://pubmed.ncbi.nlm.nih.gov/34017995/
8. Gechter, Johanna, Liebscher, Carolin, Geiger, Maximilian J, Domschke, Katharina, Ströhle, Andreas. 2019. Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls. In NeuroImage. Clinical, 24, 102029. doi:10.1016/j.nicl.2019.102029. https://pubmed.ncbi.nlm.nih.gov/31734525/
9. Henström, M, Zucchelli, M, Söderhäll, C, Olén, O, D'Amato, M. 2014. NPSR1 polymorphisms influence recurrent abdominal pain in children: a population-based study. In Neurogastroenterology and motility, 26, 1417-25. doi:10.1111/nmo.12401. https://pubmed.ncbi.nlm.nih.gov/25091462/