Otos-KO 基因敲除小鼠

1. Spracklen, Timothy F, Whitehorn, Heather, Vorster, Anna Alvera, Dalvie, Sameera, Ramesar, Rajkumar S. . Genetic variation in Otos is associated with cisplatin-induced ototoxicity. In Pharmacogenomics, 15, 1667-76. doi:10.2217/pgs.14.112. https://pubmed.ncbi.nlm.nih.gov/25410892/

2. Zhuo, Xian-Lu, Wang, Yan, Zhuo, Wen-Lei, Wei, Yun-Jun, Zhang, Xue-Yuan. 2008. Adenoviral-mediated up-regulation of Otos, a novel specific cochlear gene, decreases cisplatin-induced apoptosis of cultured spiral ligament fibrocytes via MAPK/mitochondrial pathway. In Toxicology, 248, 33-8. doi:10.1016/j.tox.2008.03.004. https://pubmed.ncbi.nlm.nih.gov/18403086/