智鼠故事 
Nt5e-KO 基因敲除小鼠
复苏/繁育服务
产品名称
Nt5e-KO 基因敲除小鼠
产品编号
S-KO-07095
品系全称
C57BL/6NCya-Nt5eem1/Cya
品系背景
C57BL/6NCya
品系编号
KOCMP-23959-Nt5e-B6N-VA
品系状态
使用本品系发表的文献需注明： Nt5e-KO 基因敲除小鼠 mice (Strain S-KO-07095) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因别称
NT，Nt5，eNT，CD73，5'-NT，2210401F01Rik
NCBI ID
染色体号
Chr 9
NCBI RefSeq
NM_011851
Ensembl ID
ENSMUST00000034992
修饰方式
全身性基因敲除
靶向范围
Exon 2~3
敲除长度
~3.5 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:99782Homozygous null mice for one allele are viable and fertile with increased circulating alkaline phosphatase and impaired tubuloglomerular feedback regulation. Homozygous null mice for a second allele display increased vascular permeability especially under hypoxic conditions.
发表文献
Life Sciences
2023-09-01
Blocking ATP-P1Rs axis attenuate alcohol-related liver fibrosis
Biochemical Pharmacology
2023-09-01
CD73 mitigates hepatic damage in alcoholic steatohepatitis by regulating PI3K/AKT-mediated hepatocyte pyroptosis
Nature Communications
2023-06-01
Transcriptional control of pancreatic cancer immunosuppression by metabolic enzyme CD73 in a tumor-autonomous and -autocrine manner
Frontiers in Pharmacology
2022-05-25
CD73-Adenosine A1R Axis Regulates the Activation and Apoptosis of Hepatic Stellate Cells Through the PLC-IP3-Ca2+/DAG-PKC Signaling Pathway
1
发表文献
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