Scap-KO 基因敲除小鼠

1. Cheng, Chunming, Geng, Feng, Li, Zoe, Cheng, Xiaolin, Guo, Deliang. 2022. Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth. In Nature metabolism, 4, 575-588. doi:10.1038/s42255-022-00568-y. https://pubmed.ncbi.nlm.nih.gov/35534729/

2. Huang, Xinyu, Yao, Yingcheng, Hou, Xiaoli, Li, Danyang, Chen, Yaxi. 2022. Macrophage SCAP Contributes to Metaflammation and Lean NAFLD by Activating STING-NF-κB Signaling Pathway. In Cellular and molecular gastroenterology and hepatology, 14, 1-26. doi:10.1016/j.jcmgh.2022.03.006. https://pubmed.ncbi.nlm.nih.gov/35367665/

3. Edwards, P A, Tabor, D, Kast, H R, Venkateswaran, A. . Regulation of gene expression by SREBP and SCAP. In Biochimica et biophysica acta, 1529, 103-13. doi:. https://pubmed.ncbi.nlm.nih.gov/11111080/

4. Liu, Fabao, Ma, Min, Gao, Ang, Li, Lingjun, Xu, Wei. 2021. PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability. In The EMBO journal, 40, e108065. doi:10.15252/embj.2021108065. https://pubmed.ncbi.nlm.nih.gov/34487377/