Apeh-KO 基因敲除小鼠

1. Brzozowska, Anna, Mlak, Radosław, Homa-Mlak, Iwona, Ciesielka, Marzanna, Małecka-Massalska, Teresa. 2018. Polymorphism of regulatory region of APEH gene (c.-521G>C, rs4855883) as a relevant predictive factor for radiotherapy induced oral mucositis and overall survival in head neck cancer patients. In Oncotarget, 9, 29644-29653. doi:10.18632/oncotarget.25662. https://pubmed.ncbi.nlm.nih.gov/30038710/

2. Tsortouktzidis, Despina, Grundke, Kathleen, Till, Claudia, Korwitz-Reichelt, Anne, Sass, Jörn Oliver. 2019. Acylpeptide hydrolase (APEH) sequence variants with potential impact on the metabolism of the antiepileptic drug valproic acid. In Metabolic brain disease, 34, 1629-1634. doi:10.1007/s11011-019-00470-9. https://pubmed.ncbi.nlm.nih.gov/31363986/

3. Riccio, Alessia, Gogliettino, Marta, Palmieri, Gianna, Monti, Giuseppe, Cocca, Ennio. 2015. A New APEH Cluster with Antioxidant Functions in the Antarctic Hemoglobinless Icefish Chionodraco hamatus. In PloS one, 10, e0125594. doi:10.1371/journal.pone.0125594. https://pubmed.ncbi.nlm.nih.gov/25946123/

4. Gogliettino, Marta, Balestrieri, Marco, Cocca, Ennio, Mazzella, Emanuela, Palmieri, Gianna. 2012. Identification and characterisation of a novel acylpeptide hydrolase from Sulfolobus solfataricus: structural and functional insights. In PloS one, 7, e37921. doi:10.1371/journal.pone.0037921. https://pubmed.ncbi.nlm.nih.gov/22655081/

5. Palmieri, Gianna, Cocca, Ennio, Gogliettino, Marta, Rossi, Mosè, Di Costanzo, Alfonso. . Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer's Disease: A Sign of Defective Proteostasis? In Journal of Alzheimer's disease : JAD, 60, 1097-1106. doi:10.3233/JAD-170389. https://pubmed.ncbi.nlm.nih.gov/28984596/

6. Tangri, Apoorva, Lighty, Kinzie, Loganathan, Jagadish, Nakshatri, Harikrishna, Mitra, Sumegha. 2021. Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma. In Molecular cancer research : MCR, 19, 1168-1181. doi:10.1158/1541-7786.MCR-20-0883. https://pubmed.ncbi.nlm.nih.gov/33753553/

7. Bergamo, Paolo, Cocca, Ennio, Palumbo, Rosanna, Rossi, Mose, Palmieri, Gianna. 2013. RedOx status, proteasome and APEH: insights into anticancer mechanisms of t10,c12-conjugated linoleic acid isomer on A375 melanoma cells. In PloS one, 8, e80900. doi:10.1371/journal.pone.0080900. https://pubmed.ncbi.nlm.nih.gov/24260504/

8. Gogliettino, Marta, Riccio, Alessia, Balestrieri, Marco, Rossi, Mosè, Palmieri, Gianna. 2013. A novel class of bifunctional acylpeptide hydrolases--potential role in the antioxidant defense systems of the Antarctic fish Trematomus bernacchii. In The FEBS journal, 281, 401-15. doi:10.1111/febs.12610. https://pubmed.ncbi.nlm.nih.gov/24206103/