Klhl22-KO 基因敲除小鼠

1. Chen, Jie, Ou, Yuhui, Yang, Yanyan, Xie, Yuntao, Liu, Ying. 2018. KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. In Nature, 557, 585-589. doi:10.1038/s41586-018-0128-9. https://pubmed.ncbi.nlm.nih.gov/29769719/

2. Zhang, Tianzhi, Liu, Jiani, Wang, Jin, Zhang, Chao. 2024. Overexpression of KLHL22 correlates with poor prognosis in patients with triple-negative breast cancer. In Translational cancer research, 13, 798-807. doi:10.21037/tcr-23-654. https://pubmed.ncbi.nlm.nih.gov/38482450/

3. Liu, X R, Wang, W, Li, H M. 2020. KLHL22 promotes malignant melanoma growth in vitro and in vivo by activating the PI3K/Akt/mTOR signaling pathway. In Neoplasma, 67, 1106-1113. doi:10.4149/neo_2020_190923N954. https://pubmed.ncbi.nlm.nih.gov/32484697/

4. Zhang, Xiaoqing, Wang, Bo, Zhang, Lichen, Zhou, Luming, Fu, Qihua. 2018. Accurate diagnosis of spinal muscular atrophy and 22q11.2 deletion syndrome using limited deoxynucleotide triphosphates and high-resolution melting. In BMC genomics, 19, 485. doi:10.1186/s12864-018-4833-4. https://pubmed.ncbi.nlm.nih.gov/29925309/

5. Loid, Petra, Pekkinen, Minna, Mustila, Taina, Lindstrand, Anna, Mäkitie, Outi. 2022. Targeted Exome Sequencing of Genes Involved in Rare CNVs in Early-Onset Severe Obesity. In Frontiers in genetics, 13, 839349. doi:10.3389/fgene.2022.839349. https://pubmed.ncbi.nlm.nih.gov/35330733/