智鼠故事 
Tnf-KO 基因敲除小鼠
复苏/繁育服务
产品名称
Tnf-KO 基因敲除小鼠
产品编号
S-KO-05505
品系全称
C57BL/6NCya-Tnfem1/Cya
品系背景
C57BL/6NCya
品系编号
KOCMP-21926-Tnf-B6N-VA
品系状态
使用本品系发表的文献需注明： Tnf-KO 基因敲除小鼠 mice (Strain S-KO-05505) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因别称
DIF，Tnfa，TNF-a，TNFSF2，Tnlg1f，Tnfsf1a，TNFalpha，TNF-alpha
NCBI ID
染色体号
Chr 17
NCBI RefSeq
NM_013693
Ensembl ID
ENSMUST00000025263
修饰方式
全身性基因敲除
靶向范围
Exon 1~4
敲除长度
~1.7 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:104798Mutations at this locus primarily affect the immune system, causing increased susceptibility to infection, failure to form splenic B-cell follicles, increased inflammation and impaired contact hypersensitivity. Homozygotes also may show metabolic defects. Combined deletions of certain regulatory regions in the 3' UTR are embryonic lethal (homozygous) or cause arthritis and intestinal and cardiac valve inflammation and reduced lifespan (heterozygous).
发表文献
Microbiology Spectrum
2022-10-01
Streptococcus suis Serotype 2 Infection Induces Splenomegaly with Splenocyte Apoptosis
1
