Tgfb1i1-KO 基因敲除小鼠

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产品名称

Tgfb1i1-KO 基因敲除小鼠

产品编号

S-KO-05370

品系全称

C57BL/6NCya-Tgfb1i1em1/Cya

品系背景

C57BL/6NCya

品系编号

KOCMP-21804-Tgfb1i1-B6N-VA

品系状态

使用本品系发表的文献需注明: Tgfb1i1-KO 基因敲除小鼠 mice (Strain S-KO-05370) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
transforming growth factor beta 1 induced transcript 1
基因别称
ARA55,Hic5,TSC-5,hic-5
染色体号
Chr 7 (Mouse)
转录本 ID
NCBI: NM_001289550 | Ensembl: ENSMUST00000167965
修饰方式
全身性基因敲除
靶向范围
Exon 1~11
敲除长度
~6.4 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:102784Mice homozygous for a knock-out allele exhibit abnormal response to wire injury of femoral arteries and increased VSMC apoptosis in response to wire injury or mechanical stress. Mice homozygous for a different knock-out allele show normal platelet integrin function both in vitro and in vivo.
Tgfb1i1,也称为TGF-β1 induced transcript 1或Hic-5,是一种在多种生物学过程中发挥重要作用的基因。Tgfb1i1的表达受到多种因素的调控,包括TGF-β1、SRF/myocardin和DNA甲基化等。

Tgfb1i1的表达与多种疾病的发生和发展密切相关。在胶质母细胞瘤中,Tgfb1i1的表达与肿瘤的恶性和预后不良相关[1]。在牙周炎中,Tgfb1i1的表达与炎症和免疫反应相关[2]。在骨肉瘤中,Tgfb1i1的表达与肿瘤的进展相关[3]。在结直肠癌中,Tgfb1i1的表达与化疗的敏感性相关[4]。此外,Tgfb1i1的表达还与平滑肌细胞的增殖和分化相关[5]。在牛的生长发育过程中,Tgfb1i1的表达与生长和发育相关[6]。在膀胱癌中,Tgfb1i1的表达与肿瘤的分期和预后相关[7,8]。在阿尔茨海默病中,Tgfb1i1的表达与铁代谢和免疫细胞浸润相关[9]。在多囊卵巢综合征中,Tgfb1i1的表达受到TGFβ的调控[10]。

综上所述,Tgfb1i1是一种重要的基因,参与调控多种生物学过程和疾病的发生和发展。Tgfb1i1的表达受到多种因素的调控,包括TGF-β1、SRF/myocardin和DNA甲基化等。Tgfb1i1的研究有助于深入理解疾病的发病机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Liu, Yanwei, Hu, Huimin, Wang, Kuanyu, Zhang, Wei, Jiang, Tao. . Multidimensional analysis of gene expression reveals TGFB1I1-induced EMT contributes to malignant progression of astrocytomas. In Oncotarget, 5, 12593-606. doi:. https://pubmed.ncbi.nlm.nih.gov/25333259/
2. Cárdenas, Angélica M, Ardila, Laura J, Vernal, Rolando, Melgar-Rodríguez, Samanta, Hernández, Hernán G. 2022. Biomarkers of Periodontitis and Its Differential DNA Methylation and Gene Expression in Immune Cells: A Systematic Review. In International journal of molecular sciences, 23, . doi:10.3390/ijms231912042. https://pubmed.ncbi.nlm.nih.gov/36233348/
3. Li, Shenglong, Wu, Xixi, Pei, Yi, Qiu, Enduo, Zhang, Xiaojing. 2019. PTHR1 May Be Involved in Progression of Osteosarcoma by Regulating miR-124-3p-AR-Tgfb1i1, miR-27a-3p-PPARG-Abca1, and miR-103/590-3p-AXIN2 Axes. In DNA and cell biology, 38, 1323-1337. doi:10.1089/dna.2019.4880. https://pubmed.ncbi.nlm.nih.gov/31536386/
4. Li, Shaotang, Lu, Xingrong, Chi, Pan, Pan, Jie. 2012. Identification of Nkx2-3 and TGFB1I1 expression levels as potential biomarkers to predict the effects of FOLFOX4 chemotherapy. In Cancer biology & therapy, 13, 443-9. doi:10.4161/cbt.19298. https://pubmed.ncbi.nlm.nih.gov/22313639/
5. Wang, Xiaobo, Hu, Guoqing, Betts, Courtney, Van De Water, Livingston, Zhou, Jiliang. 2011. Transforming growth factor-β1-induced transcript 1 protein, a novel marker for smooth muscle contractile phenotype, is regulated by serum response factor/myocardin protein. In The Journal of biological chemistry, 286, 41589-41599. doi:10.1074/jbc.M111.250878. https://pubmed.ncbi.nlm.nih.gov/21984848/
6. Chang, Chencheng, Yang, Yanda, Zhou, Le, Shi, Caixia, Zhang, Wenguang. 2023. Candidate Genes and Gene Networks Change with Age in Japanese Black Cattle by Blood Transcriptome Analysis. In Genes, 14, . doi:10.3390/genes14020504. https://pubmed.ncbi.nlm.nih.gov/36833431/
7. Di, Yu, Chen, Dongshan, Yu, Wei, Yan, Lei. 2019. Bladder cancer stage-associated hub genes revealed by WGCNA co-expression network analysis. In Hereditas, 156, 7. doi:10.1186/s41065-019-0083-y. https://pubmed.ncbi.nlm.nih.gov/30723390/
8. Luo, Lianmin, Li, Fenghua, Gong, Binbin, Xi, Ping, Xie, Wenjie. 2022. A novel prognostic model based on cellular senescence-related gene signature for bladder cancer. In Frontiers in oncology, 12, 937951. doi:10.3389/fonc.2022.937951. https://pubmed.ncbi.nlm.nih.gov/36505846/
9. Zhang, Lusi, Fang, Jia, Tang, Zhenchu, Luo, Yingying. 2022. A Bioinformatics Perspective on the Dysregulation of Ferroptosis and Ferroptosis-related Immune Cell Infiltration in Alzheimer's Disease. In International journal of medical sciences, 19, 1888-1902. doi:10.7150/ijms.76660. https://pubmed.ncbi.nlm.nih.gov/36438927/
10. Azumah, Rafiatu, Liu, Menghe, Hummitzsch, Katja, Anderson, Richard A, Rodgers, Raymond J. . Candidate genes for polycystic ovary syndrome are regulated by TGFβ in the bovine foetal ovary. In Human reproduction (Oxford, England), 37, 1244-1254. doi:10.1093/humrep/deac049. https://pubmed.ncbi.nlm.nih.gov/35413103/