智鼠故事 
Trim21-KO 基因敲除小鼠
复苏/繁育服务
产品名称
Trim21-KO 基因敲除小鼠
产品编号
S-KO-04542
品系全称
C57BL/6NCya-Trim21em1/Cya
品系背景
C57BL/6NCya
品系编号
KOCMP-20821-Trim21-B6N-VA
品系状态
使用本品系发表的文献需注明： Trim21-KO 基因敲除小鼠 mice (Strain S-KO-04542) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因全称
tripartite motif-containing 21
基因别称
Ro52，Ssa1
染色体号
Chr 7 (Mouse)
NCBI ID
转录本 ID
NCBI: NM_009277 | Ensembl: ENSMUST00000033264
修饰方式
全身性基因敲除
靶向范围
Exon 3~6
敲除长度
~3.5 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:106657Mice homozygous for a null allele display reduced survival and abnormal immune responses. Mice homozygous for a second null allele display increased salivation.
发表文献
Molecular Therapy
2025-02-03
Targeting the TRIM21-PD-1 axis potentiates immune checkpoint blockade and CAR-T cell therapy
Bone Research
2023-10-25
Trim21 depletion alleviates bone loss in osteoporosis via activation of YAP1/β-catenin signaling
Cell Metabolism
2023-08-08
UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders
Frontiers in Immunology
2018
TRIM21 Restricts Coxsackievirus B3 Replication, Cardiac and Pancreatic Injury via Interacting With MAVS and Positively Regulating IRF3-Mediated Type-I Interferon Production
1
发表文献
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