Serpini1-KO 基因敲除小鼠

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产品名称

Serpini1-KO 基因敲除小鼠

产品编号

S-KO-04440

品系全称

C57BL/6JCya-Serpini1em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-20713-Serpini1-B6J-VA

品系状态

使用本品系发表的文献需注明: Serpini1-KO 基因敲除小鼠 mice (Strain S-KO-04440) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
serine (or cysteine) peptidase inhibitor, clade I, member 1
基因别称
Ns,PI-12,PI12,Spi17
染色体号
Chr 3 (Mouse)
转录本 ID
NCBI: NM_009250.3 | Ensembl: ENSMUST00000029423
修饰方式
全身性基因敲除
靶向范围
Exon 3~5
敲除长度
~4870 bp
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:1194506Mice homozygous for a disruption in this gene show no change in brain morphology or histology. However, they show an increase avoidance of novel stimuli and increased anxiety responses in some situations.
Serpini1,也称为Neuroserpin,是一种在神经系统中具有重要功能的基因。它编码一种丝氨酸蛋白酶抑制剂,参与调节神经递质的释放和神经元的发育。Serpini1的突变会导致家族性脑病,这是一种罕见的神经退行性疾病,以神经丝蛋白包涵体为特征。

Serpini1的表达和功能与多种神经系统疾病相关。研究表明,Serpini1的表达水平在家族性脑病患者中显著降低,这表明Serpini1在维持神经系统功能方面发挥着重要作用[2]。此外,Serpini1的表达水平在精神分裂症患者中也有显著变化,这表明Serpini1可能与精神分裂症的发病机制有关[6]。

Serpini1的表达和功能还与肿瘤的发生和发展相关。研究表明,Serpini1的表达水平在胃癌和膀胱癌等多种肿瘤中显著降低,这表明Serpini1可能是一种肿瘤抑制基因[1,7]。此外,Serpini1的表达和功能还与上皮间质转化(EMT)相关,这是一种在肿瘤侵袭和转移中发挥重要作用的生物学过程[5]。

Serpini1的表达和功能受到多种因素的调控。研究表明,microRNA-21可以抑制Serpini1的表达,从而促进胃癌的发生和发展[1]。此外,c-Myc转录因子可以调节Serpini1和PDCD10基因的协同转录,这表明Serpini1的表达和功能可能受到复杂的基因调控网络的调控[3,4]。

综上所述,Serpini1是一种重要的基因,参与调节神经系统的功能和肿瘤的发生和发展。Serpini1的表达和功能受到多种因素的调控,包括microRNA和转录因子。Serpini1的研究有助于深入理解神经系统疾病和肿瘤的发生机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Yamanaka, Sumitaka, Olaru, Alexandru V, An, Fangmei, Meltzer, Stephen J, Selaru, Florin M. 2012. MicroRNA-21 inhibits Serpini1, a gene with novel tumour suppressive effects in gastric cancer. In Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 44, 589-96. doi:10.1016/j.dld.2012.02.016. https://pubmed.ncbi.nlm.nih.gov/22464652/
2. Yang, Xiaoyue, Fang, Zhixu, Yan, Lisi, Cheng, Min, Jiang, Li. 2022. Role of SERPINI1 pathogenic variants in familial encephalopathy with neuroserpin inclusion bodies: A case report and literature review. In Seizure, 103, 137-147. doi:10.1016/j.seizure.2022.11.008. https://pubmed.ncbi.nlm.nih.gov/36417830/
3. Chen, Ping-Yen, Chang, Wun-Shaing W, Lai, Yiu-Kay, Wu, Cheng-Wen. 2009. c-Myc regulates the coordinated transcription of brain disease-related PDCD10-SERPINI1 bidirectional gene pair. In Molecular and cellular neurosciences, 42, 23-32. doi:10.1016/j.mcn.2009.05.001. https://pubmed.ncbi.nlm.nih.gov/19442737/
4. Chen, Ping-Yen, Chang, Wun-Shaing W, Chou, Ruey-Hwang, Chi, Chia-Yi, Wu, Cheng-Wen. 2007. Two non-homologous brain diseases-related genes, SERPINI1 and PDCD10, are tightly linked by an asymmetric bidirectional promoter in an evolutionarily conserved manner. In BMC molecular biology, 8, 2. doi:. https://pubmed.ncbi.nlm.nih.gov/17212813/
5. Matsuda, Yasufumi, Miura, Koh, Yamane, Junko, Naitoh, Takeshi, Unno, Michiaki. 2016. SERPINI1 regulates epithelial-mesenchymal transition in an orthotopic implantation model of colorectal cancer. In Cancer science, 107, 619-28. doi:10.1111/cas.12909. https://pubmed.ncbi.nlm.nih.gov/26892864/
6. Vawter, Marquis P, Shannon Weickert, Cynthia, Ferran, Erick, Bunney, William E, Kleinman, Joel E. . Gene expression of metabolic enzymes and a protease inhibitor in the prefrontal cortex are decreased in schizophrenia. In Neurochemical research, 29, 1245-55. doi:. https://pubmed.ncbi.nlm.nih.gov/15176481/
7. Yang, Zeyu, Liu, Anwei, Xiong, Qiao, Sun, Yinghao, Xu, Chuanliang. 2019. Prognostic value of differentially methylated gene profiles in bladder cancer. In Journal of cellular physiology, 234, 18763-18772. doi:10.1002/jcp.28515. https://pubmed.ncbi.nlm.nih.gov/30953370/