MGI:1340062Homozygous knockout results in reduced sensitivity to hypoxia-induced pulmonary arterial hypertension, inflammation and cardiac ventricular hypertrophy. But otherwise mice display an essentially normal phenotype. Sodium retention is compromised on a low salt diet.
Serum/glucocorticoid-inducible kinase 1 deficiency induces NLRP3 inflammasome activation and autoinflammation of macrophages in a murine endolymphatic hydrops model