Nr1h4-KO 基因敲除小鼠

1. Lai, Hua, Liu, Xianxian, Xin, Siming, Zou, Yang, Zeng, Xiaoming. 2022. Identification of two novel pathogenic variants of the NR1H4 gene in intrahepatic cholestasis of pregnancy patients. In BMC medical genomics, 15, 90. doi:10.1186/s12920-022-01240-w. https://pubmed.ncbi.nlm.nih.gov/35436901/

2. Chiang, John Y L, Ferrell, Jessica M. 2022. Discovery of farnesoid X receptor and its role in bile acid metabolism. In Molecular and cellular endocrinology, 548, 111618. doi:10.1016/j.mce.2022.111618. https://pubmed.ncbi.nlm.nih.gov/35283218/

3. Huang, Shiyu, Hou, Yanguang, Hu, Min, Hu, Juncheng, Liu, Xiuheng. 2022. Clinical significance and oncogenic function of NR1H4 in clear cell renal cell carcinoma. In BMC cancer, 22, 995. doi:10.1186/s12885-022-10087-4. https://pubmed.ncbi.nlm.nih.gov/36123627/

4. Ma, Yingxuan, Lu, Li, Tan, Kezhe, Mo, Jiayu, Gong, Zhenhua. 2022. Reduced peroxisome proliferator-activated receptor-α and bile acid nuclear receptor NR1H4/FXR may affect the hepatic immune microenvironment of biliary atresia. In Frontiers in immunology, 13, 875593. doi:10.3389/fimmu.2022.875593. https://pubmed.ncbi.nlm.nih.gov/36090996/

5. Chen, Xiu-Qi, Wang, Lin-Lin, Shan, Qing-Wen, Lian, Shu-Jun, Yun, Xiang. 2011. A novel heterozygous NR1H4 termination codon mutation in idiopathic infantile cholestasis. In World journal of pediatrics : WJP, 8, 67-71. doi:10.1007/s12519-011-0299-z. https://pubmed.ncbi.nlm.nih.gov/21633855/