智鼠故事 
C57BL/6NCya-Nfe2l2em1/Cya 全身性基因敲除小鼠
复苏/繁育服务
产品名称
Nfe2l2-KO
产品编号
S-KO-03360
品系全称
C57BL/6NCya-Nfe2l2em1/Cya
品系背景
C57BL/6NCya
品系编号
KOCMP-18024-Nfe2l2-B6N-VA
品系状态
使用本品系发表的文献需注明： Nfe2l2-KO mice (Strain S-KO-03360) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因别称
Nrf2
NCBI ID
染色体号
Chr 2
NCBI RefSeq
NM_010902
Ensembl ID
ENSMUST00000102672
修饰方式
全身性基因敲除
靶向范围
Exon 2~5
敲除长度
~5.0 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:108420Nullizygous mice show increased sensitivity to oxidative stress in a variety of organs and cells, abnormal tooth enamel, altered response to various injuries, chemical treatments and induced inflammatory diseases, and an age-related decline in spermatogenesis and ovarian follicle numbers.
发表文献
Food Science and Human Wellness
2024-03-01
Functionalized selenium nanoparticles ameliorated acetaminophen-induced hepatotoxicity through synergistically triggering PKCδ/Nrf2 signaling pathway and inhibiting CYP 2E1
Free Radical Biology and Medicine
2023-02-01
17β-estradiol plays the anti-osteoporosis role via a novel ESR1-Keap1-Nrf2 axis-mediated stress response activation and Tmem119 upregulation
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