Mfap2-KO 基因敲除小鼠

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产品名称

Mfap2-KO 基因敲除小鼠

产品编号

S-KO-03113

品系全称

C57BL/6JCya-Mfap2em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-17150-Mfap2-B6J-VA

品系状态

使用本品系发表的文献需注明: Mfap2-KO 基因敲除小鼠 mice (Strain S-KO-03113) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
microfibrillar-associated protein 2
基因别称
MAGP-1,MFAP-2,Magp,Magp1
染色体号
Chr 4 (Mouse)
转录本 ID
NCBI: NM_008546 | Ensembl: ENSMUST00000071977
修饰方式
全身性基因敲除
靶向范围
Exon 2~9
敲除长度
~3.8 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:99559Homozygotes for a knock-out allele show thrombocytopenia, delayed thrombotic occlusion following vessel injury, and prolonged bleeding from a tail vein incision. Homozygotes for a different knock-out allele exhibit marrow adipose tissue expansion, insulin resistance, and altered basal hematopoiesis.
MFAP2,也称为微原纤维相关蛋白2,是一种存在于细胞外基质中的蛋白质。MFAP2通过其与原纤维素的相互作用来调节原纤维的活性。研究表明,MFAP2在多种癌症中表达上调,并与肿瘤的发生、发展和预后密切相关。

在肝纤维化中,MFAP2的表达升高,并通过FBN1/TGF-β/Smad3通路促进肝星状细胞(HSCs)的活化,导致细胞外基质的积累和肝纤维化的发生[1]。此外,MFAP2在结直肠癌中表达上调,并通过CLK3信号通路促进肿瘤的侵袭和转移[3]。在乳腺癌中,MFAP2的表达升高与患者的不良预后相关,并可能成为免疫治疗的潜在靶点[2][4]。在卵巢癌中,MFAP2通过激活FOXM1/β-catenin介导的糖酵解信号通路促进肿瘤的进展[6]。在胃癌中,MFAP2的表达升高与肿瘤的侵袭和转移相关,并通过调节自噬影响顺铂的耐药性[5][7]。在甲状腺癌中,MFAP2的表达升高与肿瘤的进展相关,并可能成为潜在的诊疗靶点[8]。

综上所述,MFAP2在多种癌症中表达上调,并参与肿瘤的发生、发展和预后。MFAP2可能成为癌症诊疗和治疗的潜在靶点,并为未来研究提供新的思路和策略。

参考文献:
1. Sun, Yonghong, Chen, Xingxing, Chen, Lili, Li, Chunming, Zhou, Yongning. 2023. MFAP2 promotes HSCs activation through FBN1/TGF-β/Smad3 pathway. In Journal of cellular and molecular medicine, 27, 3235-3246. doi:10.1111/jcmm.17884. https://pubmed.ncbi.nlm.nih.gov/37635348/
2. Huang, Jing, Xu, Yuting, Qi, Shengnan, Liu, Lei, Liu, Fan. 2024. The potent potential of MFAP2 in prognosis and immunotherapy of triple-negative breast cancer. In Discover oncology, 15, 202. doi:10.1007/s12672-024-01044-7. https://pubmed.ncbi.nlm.nih.gov/38822944/
3. Xue, Meng, Mi, Shuyi, Zhang, Zizhen, Wei, Wei, Lou, Guochun. 2022. MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3. In Cancer medicine, 12, 8403-8414. doi:10.1002/cam4.5561. https://pubmed.ncbi.nlm.nih.gov/36583532/
4. Yu, Jingjing, Wang, Fengbo, Dong, Rui, Jia, Wei. 2024. The use of MFAP2 for diagnosis, prognosis and immunotherapy of triple-negative breast cancer. In American journal of translational research, 16, 1322-1336. doi:10.62347/BLDG4505. https://pubmed.ncbi.nlm.nih.gov/38715831/
5. Li, Meng, Zhang, Hong-Yi, Zhang, Rong-Gui. 2023. MFAP2 enhances cisplatin resistance in gastric cancer cells by regulating autophagy. In PeerJ, 11, e15441. doi:10.7717/peerj.15441. https://pubmed.ncbi.nlm.nih.gov/37304872/
6. Zhao, Ling-Qin, Sun, Wei, Zhang, Ping, Fang, Chen-Yan, Zheng, Ai-Wen. 2022. MFAP2 aggravates tumor progression through activating FOXM1/β-catenin-mediated glycolysis in ovarian cancer. In The Kaohsiung journal of medical sciences, 38, 772-780. doi:10.1002/kjm2.12546. https://pubmed.ncbi.nlm.nih.gov/35546486/
7. Yao, Li-Wen, Wu, Lian-Lian, Zhang, Li-Hui, Yang, Yan-Ning, Yu, Hong-Gang. 2020. MFAP2 is overexpressed in gastric cancer and promotes motility via the MFAP2/integrin α5β1/FAK/ERK pathway. In Oncogenesis, 9, 17. doi:10.1038/s41389-020-0198-z. https://pubmed.ncbi.nlm.nih.gov/32054827/
8. Dong, Si Yang, Chen, Hao, Lin, Li Zhi, Wang, Ou Chen, Ye, Zhi Qiang. 2020. MFAP2 is a Potential Diagnostic and Prognostic Biomarker That Correlates with the Progression of Papillary Thyroid Cancer. In Cancer management and research, 12, 12557-12567. doi:10.2147/CMAR.S274986. https://pubmed.ncbi.nlm.nih.gov/33324100/