Il1rn-KO 基因敲除小鼠

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产品名称

Il1rn-KO 基因敲除小鼠

产品编号

S-KO-02639

品系全称

C57BL/6JCya-Il1rnem1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-16181-Il1rn-B6J-VA

品系状态

使用本品系发表的文献需注明: Il1rn-KO 基因敲除小鼠 mice (Strain S-KO-02639) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
interleukin 1 receptor antagonist
基因别称
F630041P17Rik,IL-1ra
染色体号
Chr 2 (Mouse)
转录本 ID
NCBI: NM_001039701.3 | Ensembl: ENSMUST00000114482
修饰方式
全身性基因敲除
靶向范围
Exon 2~3
敲除长度
~2.0 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:96547Nullizygous mutations of this gene may result in decreased body weight, increased inflammatory response to turpentine and LPS, decreased susceptibility to bacterial infection, psoriasis, aortitis, rheumatoid arthritis, and abnormal dendritic and CD4-positive T cell morphology.
基因IL1RN,也称为IL-1受体拮抗剂(IL-1Ra),是一种重要的免疫调节因子。它通过结合IL-1受体,阻止IL-1α和IL-1β与受体结合,从而抑制这两种细胞因子的生物学活性。IL-1Ra在生理和病理免疫及炎症反应中发挥着重要作用,包括调节炎症反应、免疫应答和细胞凋亡等。

IL1RN基因定位于人类染色体2q14区域,与IL-1α、IL-1β以及IL-1受体基因相邻。IL1RN基因的长度变异多态性(VNTR)已被广泛研究,并被发现与多种疾病相关。例如,研究发现,IL1RN VNTR基因型2/2在复发性妊娠丢失(RPL)患者中的频率显著高于对照组[1]。此外,IL1RN基因的变异还与Tourette综合征的易感性相关[3],并且在特发性肺纤维化(IPF)患者中,IL1RN基因的SNP与疾病易感性和细胞因子水平相关[4]。

除了上述疾病,IL1RN基因还与急性胰腺炎(AP)的发生有关。一项Mendelian随机化研究发现,IL1RN基因与AP的发生风险相关,并且IL27基因与AP的发生风险呈负相关[2]。此外,IL1RN基因在T细胞前淋巴细胞白血病(T-PLL)中的表达水平也与其分子亚型相关[5]。

除了在疾病中的作用,IL1RN基因的表达还受到多种因素的调控。例如,研究发现,IL1RN基因的表达受IL-1β、TNF-α和IL-6等细胞因子的调控。此外,IL1RN基因的表达还受到转录因子NF-κB的调控。

综上所述,IL1RN基因是一种重要的免疫调节因子,在多种疾病中发挥重要作用。IL1RN基因的变异与RPL、Tourette综合征、IPF、AP和T-PLL等疾病相关。此外,IL1RN基因的表达还受到多种因素的调控。研究IL1RN基因的功能和调控机制,有助于深入理解免疫系统的功能和疾病发生机制,为疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Nair, R. R., Khanna, A., Ravindran, R., & Singh, K. (2014). Association of interleukin 1 receptor antagonist (IL1RN) gene polymorphism with recurrent pregnancy loss risk in the North Indian Population and a meta-analysis. Molecular biology reports, 41(9), 5719-5727.
2. Jing, Q., Liu, X., Lv, Z., & Xue, D. (2024). IL27 and IL1RN are causally associated with acute pancreatitis: a Mendelian randomization study. Aging, 16(8), 8572-8584.
3. Chou, I. C., Lin, H. C., Wang, C. H., Tsai, C. H., & Tsai, F. J. (2010). Polymorphisms of interleukin 1 gene IL1RN are associated with Tourette syndrome. Pediatric neurology, 42(4), 320-324.
4. Patterson, D., Jones, C., Hart, I., Smith, M. F., & Arend, W. P. (1993). The human interleukin-1 receptor antagonist (IL1RN) gene is located in the chromosome 2q14 region. Genomics, 15(1), 173-176.
5. Steinkasserer, A., Spurr, N. K., Cox, S., Jeggo, P., & Sim, R. B. (1992). The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci. Genomics, 13(4), 654-657.
6. Barlo, N. P., van Moorsel, C. H., Korthagen, N. M., van den Bosch, J. M., & Grutters, J. C. (2011). Genetic variability in the IL1RN gene and the balance between interleukin (IL)-1 receptor agonist and IL-1β in idiopathic pulmonary fibrosis. Clinical and experimental immunology, 166(2), 346-351.
7. Mikhaylenko, N., Wahnschaffe, L., Herling, M., Roeder, I., & Seifert, M. (2022). Computational gene expression analysis reveals distinct molecular subgroups of T-cell prolymphocytic leukemia. PLoS one, 17(3), e0274463.
参考文献:
1. Nair, Rohini Ravindran, Khanna, Anuradha, Singh, Kiran. 2014. Association of interleukin 1 receptor antagonist (IL1RN) gene polymorphism with recurrent pregnancy loss risk in the North Indian Population and a meta-analysis. In Molecular biology reports, 41, 5719-27. doi:10.1007/s11033-014-3443-8. https://pubmed.ncbi.nlm.nih.gov/24952603/
2. Jing, Qingxu, Liu, Xuxu, Lv, Zhenyi, Xue, Dongbo. 2024. IL27 and IL1RN are causally associated with acute pancreatitis: a Mendelian randomization study. In Aging, 16, 8572-8584. doi:10.18632/aging.205825. https://pubmed.ncbi.nlm.nih.gov/38742942/
3. Chou, I-Ching, Lin, Hung-Chih, Wang, Chung-Hsing, Tsai, Chang-Hai, Tsai, Fuu-Jen. . Polymorphisms of interleukin 1 gene IL1RN are associated with Tourette syndrome. In Pediatric neurology, 42, 320-4. doi:10.1016/j.pediatrneurol.2010.01.006. https://pubmed.ncbi.nlm.nih.gov/20399384/
4. Barlo, N P, van Moorsel, C H M, Korthagen, N M, van den Bosch, J M M, Grutters, J C. . Genetic variability in the IL1RN gene and the balance between interleukin (IL)-1 receptor agonist and IL-1β in idiopathic pulmonary fibrosis. In Clinical and experimental immunology, 166, 346-51. doi:10.1111/j.1365-2249.2011.04468.x. https://pubmed.ncbi.nlm.nih.gov/22059992/
5. Mikhaylenko, Nathan, Wahnschaffe, Linus, Herling, Marco, Roeder, Ingo, Seifert, Michael. 2022. Computational gene expression analysis reveals distinct molecular subgroups of T-cell prolymphocytic leukemia. In PloS one, 17, e0274463. doi:10.1371/journal.pone.0274463. https://pubmed.ncbi.nlm.nih.gov/36129940/