Hmga1-KO 基因敲除小鼠

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产品名称

Hmga1-KO 基因敲除小鼠

产品编号

S-KO-02464

品系全称

C57BL/6JCya-Hmga1em1/Cya

品系背景

C57BL/6JCya

品系编号

KOCMP-15361-Hmga1-B6J-VA

品系状态

使用本品系发表的文献需注明: Hmga1-KO 基因敲除小鼠 mice (Strain S-KO-02464) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量

基本信息

基因研究概述

质控标准

基因
基因全称
high mobility group AT-hook 1
基因别称
Hmga1a,Hmga1b,Hmgi,Hmgiy,Hmgy
染色体号
Chr 17 (Mouse)
转录本 ID
NCBI: NM_016660 | Ensembl: ENSMUST00000231874
修饰方式
全身性基因敲除
靶向范围
Exon 2~4
敲除长度
~2.0 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:96160Although haploinsufficiency at this locus is not compatible with germline transmission of one allele at this locus, mice homozygous for two other disruptions are fertile. Abnormalities are seen in glucose metabolism and in the cardiovascular system.
HMGA1,也称为高迁移率族蛋白A1,是一种重要的非组蛋白染色质蛋白,具有多种生物学功能。HMGA1在胚胎发育、细胞生长、分化和肿瘤发生等过程中发挥着关键作用。作为一种染色质重塑因子,HMGA1能够调节基因表达,影响细胞增殖、凋亡和炎症反应。近年来,越来越多的研究表明,HMGA1在多种癌症中异常表达,与肿瘤的发生、发展、转移和预后密切相关。

HMGA1是一种染色质重塑因子,参与基因转录和染色质重塑过程。它能够与DNA结合,影响基因表达和细胞功能。在多种癌症中,HMGA1的表达水平异常升高,与肿瘤的发生、发展、转移和预后密切相关。例如,在胰腺导管腺癌中,HMGA1通过上调FGF19的表达,促进肿瘤的发生和进展,以及肿瘤间质的形成[2]。此外,HMGA1还与乳腺癌、肺癌等多种癌症的发生和发展密切相关。在乳腺癌中,HMGA1的表达水平与雌激素受体(ER)阴性相关,高表达HMGA1的患者预后较差[8]。在非小细胞肺癌(NSCLC)患者中,血液中HMGA1的表达水平与患者的吸烟状态相关,且高表达HMGA1的患者预后较差[4]。

HMGA1在细胞凋亡和炎症反应中也发挥着重要作用。在LPS诱导的心肌炎症模型中,HMGA1的表达水平升高,且过表达HMGA1会加剧心肌细胞的炎症和凋亡[1]。此外,HMGA1还与细胞衰老和基因表达调控密切相关。在细胞衰老过程中,HMGA1能够影响染色质的高级结构,协调基因表达,从而影响细胞衰老的异质性[7]。

HMGA1通过多种机制参与基因表达的调控。例如,HMGA1可以与FoxO1基因的启动子结合,增加FoxO1的表达,从而影响葡萄糖代谢和细胞增殖[6]。此外,HMGA1还能够与GATA2基因的启动子结合,增加GATA2的表达,从而影响细胞的增殖和分化[3]。HMGA1还与胰岛素抵抗相关,地中海饮食中的营养素可以通过影响HMGA1的表达,改善胰岛素抵抗和相关的疾病[5]。

综上所述,HMGA1是一种重要的染色质重塑因子,参与基因表达调控、细胞凋亡和炎症反应等生物学过程。HMGA1在多种癌症中异常表达,与肿瘤的发生、发展、转移和预后密切相关。此外,HMGA1还与细胞衰老和基因表达调控密切相关。HMGA1的研究有助于深入理解染色质重塑和基因表达调控的机制,为癌症等疾病的治疗和预防提供新的思路和策略。

参考文献:
1. Cai, Zhu-Lan, Shen, Bo, Yuan, Yuan, Wu, Qing-Qing, Tang, Qi-Zhu. 2020. The effect of HMGA1 in LPS-induced Myocardial Inflammation. In International journal of biological sciences, 16, 1798-1810. doi:10.7150/ijbs.39947. https://pubmed.ncbi.nlm.nih.gov/32398950/
2. Chia, Lionel, Wang, Bowen, Kim, Jung-Hyun, Wood, Laura, Resar, Linda. 2023. HMGA1 induces FGF19 to drive pancreatic carcinogenesis and stroma formation. In The Journal of clinical investigation, 133, . doi:10.1172/JCI151601. https://pubmed.ncbi.nlm.nih.gov/36919699/
3. Li, Liping, Kim, Jung-Hyun, Lu, Wenyan, Moliterno, Alison R, Resar, Linda M S. . HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression. In Blood, 139, 2797-2815. doi:10.1182/blood.2021013925. https://pubmed.ncbi.nlm.nih.gov/35286385/
4. Saed, Lias, Balcerczak, Ewa, Łochowski, Mariusz, Olechnowicz, Ewa, Sałagacka-Kubiak, Aleksandra. 2022. HMGA1 gene expression level in cancer tissue and blood samples of non-small cell lung cancer (NSCLC) patients: preliminary report. In Molecular genetics and genomics : MGG, 297, 1505-1514. doi:10.1007/s00438-022-01936-9. https://pubmed.ncbi.nlm.nih.gov/35948739/
5. Mirabelli, Maria, Chiefari, Eusebio, Arcidiacono, Biagio, Foti, Daniela Patrizia, Brunetti, Antonio. 2020. Mediterranean Diet Nutrients to Turn the Tide against Insulin Resistance and Related Diseases. In Nutrients, 12, . doi:10.3390/nu12041066. https://pubmed.ncbi.nlm.nih.gov/32290535/
6. Arcidiacono, Biagio, Chiefari, Eusebio, Messineo, Sebastiano, Foti, Daniela P, Brunetti, Antonio. 2017. HMGA1 is a novel transcriptional regulator of the FoxO1 gene. In Endocrine, 60, 56-64. doi:10.1007/s12020-017-1445-8. https://pubmed.ncbi.nlm.nih.gov/29052178/
7. Olan, Ioana, Ando-Kuri, Masami, Parry, Aled J, Narita, Masako, Narita, Masashi. 2024. HMGA1 orchestrates chromatin compartmentalization and sequesters genes into 3D networks coordinating senescence heterogeneity. In Nature communications, 15, 6891. doi:10.1038/s41467-024-51153-8. https://pubmed.ncbi.nlm.nih.gov/39134516/
8. Gorbounov, Mikhail, Carleton, Neil M, Asch-Kendrick, Rebecca J, Bae, Young Kyung, Resar, Linda M S. 2019. High mobility group A1 (HMGA1) protein and gene expression correlate with ER-negativity and poor outcomes in breast cancer. In Breast cancer research and treatment, 179, 25-35. doi:10.1007/s10549-019-05419-1. https://pubmed.ncbi.nlm.nih.gov/31531802/