MGI:95663Homozygous inactivation of this gene causes embryonic lethality and a variety of embryonic defects. Homozygotes for a spontaneous allele show partial hair loss and defects in hair structure and hair growth cycle regulation. Homozygotes for a null allele show severe cardiac outflow tract defects, such as ventricular septal defect, double outlet right ventricle, aortic arch anomalies and persistent truncus arteriosus.