Fmo5-KO 基因敲除小鼠

1. Kong, Lingjian, Chen, Jing, Ji, Xiaoli, Li, Deliang, Sun, Meiling. 2021. Alcoholic fatty liver disease inhibited the co-expression of Fmo5 and PPARα to activate the NF-κB signaling pathway, thereby reducing liver injury via inducing gut microbiota disturbance. In Journal of experimental & clinical cancer research : CR, 40, 18. doi:10.1186/s13046-020-01782-w. https://pubmed.ncbi.nlm.nih.gov/33413501/

2. Schaller, Megan L, Sykes, Madeline M, Mecano, Joy, Shah, Yatrik M, Leiser, Scott F. 2024. Fmo5 plays a sex-specific role in goblet cell maturation and mucus barrier formation. In bioRxiv : the preprint server for biology, , . doi:10.1101/2024.04.05.588360. https://pubmed.ncbi.nlm.nih.gov/38645243/

3. Phillips, Ian R, Veeravalli, Sunil, Khadayate, Sanjay, Shephard, Elizabeth A. 2023. Metabolomic and transcriptomic analyses of Fmo5-/- mice reveal roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated oxidative stress response, unfolded protein response, lipid homeostasis, and carbohydrate and one-carbon metabolism. In PloS one, 18, e0286692. doi:10.1371/journal.pone.0286692. https://pubmed.ncbi.nlm.nih.gov/37267233/

4. Fiorentini, Filippo, Geier, Martina, Binda, Claudia, Hall, Mélanie, Mattevi, Andrea. 2016. Biocatalytic Characterization of Human FMO5: Unearthing Baeyer-Villiger Reactions in Humans. In ACS chemical biology, 11, 1039-48. doi:10.1021/acschembio.5b01016. https://pubmed.ncbi.nlm.nih.gov/26771671/

5. Veeravalli, Sunil, Varshavi, Dorsa, Scott, Flora H, Everett, Jeremy R, Shephard, Elizabeth A. 2022. Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5 -/- mice, decreases plasma cholesterol and epididymal fat deposition. In Frontiers in physiology, 13, 859681. doi:10.3389/fphys.2022.859681. https://pubmed.ncbi.nlm.nih.gov/36003643/